| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4685760 | B | Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation measured after 16 hrs by immunoblotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4685763 | B | Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation by measuring remaining BCL-XL level at 100 nM measured after 16 hrs by immunoblotting analysis relative to control | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 3. | ALA5054266 | B | Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 10 uM pretreated with VHL-032 followed by compound treatement measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5054267 | B | Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 10 uM pretreated with MG-132 followed by compound treatement measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5054268 | B | Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 100 nM measured up to 72 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5054270 | B | Protac activity at VHL/BCL-XL in human platelets assessed as decrease in BCL-XL protein level at up to 1000 uM measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 7. | ALA5054272 | B | Protac activity at VHL/BCL-XL in human RS4-11 cells assessed as decrease in BCL-XL protein level by densitometric analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA5054273 | B | Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as decrease in BCL-XL protein level by densitometric analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA5054274 | B | Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5054277 | B | Protac activity at VHL/BCL-XL in human MOLT-4 assessed as decrease in BCL-XL protein level at up to 1000 uM measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA5054278 | B | Protac activity at VHL/BCL-XL in human RS4-11 assessed as decrease in BCL-XL protein level at up to 1000 uM measured after 16 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA5054292 | B | Binding affinity to Halo-tagged VHL/HiBiT-tagged BCL-XL (unknown origin) expressed in HEK293T cells assessed as ternary complex formation at up to 100000 nM measured after 6 hrs by NanoBRET assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA5054295 | B | Binding affinity to VHL/ BCL-XL in human RS4-11 cells assessed as ternary complex formation at up to 300 nM measured after 12 hrs by immunoprecipitation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA5054297 | B | Binding affinity to VHL/ BCL-XL in human RS4-11 cells assessed as ternary complex formation at up to 300 nM measured after 12 hrs in presence of VHL-032 by immunoprecipitation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA5104685 | B | PROTAC activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation incubated for 16 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5104686 | B | PROTAC activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation incubated for 16 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5108724 | B | PROTAC activity at VHL/Bcl-xL in human MOLT-4 cells assessed as induction of Bcl-xL degradation incubated for 16 hrs by immunoblot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5108725 | B | PROTAC activity at VHL/Bcl-xL in human MOLT-4 cells assessed as induction of Bcl-xL degradation incubated for 16 hrs by immunoblot assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5108731 | B | PROTAC activity at VHL/Bcl-xL in human THP-1 cells assessed as induction of Bcl-xL degradation incubated for 24 hrs by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5108732 | B | PROTAC activity at VHL/Bcl-xL in human THP-1 cells assessed as induction of Bcl-xL degradation incubated for 24 hrs by Western blot assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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