| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4733695 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 10 uM after 10 hrs by Western blotting analysis (Rvb = 95.3 to 100.6 %) | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
| 2. | ALA4733697 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 8.3 uM preincubated for 2 hrs with VHL ligand, pomalidomide followed by compound addition and measured after 8 hrs by Western blotting analysis (Rvb = 100 %) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4733698 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 2.8 uM after 10 hrs by Western blotting analysis (Rvb = 100 %) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4733699 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 8.3 uM after 10 hrs by Western blotting analysis (Rvb = 100 %) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4733700 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 25 uM after 10 hrs by Western blotting analysis (Rvb = 100 %) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4733701 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 8.3 uM preincubated for 2 hrs with proteasome inhibitor, MG132 followed by compound addition and measured after 8 hrs by Western blotting analysis (Rvb = 100 %) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4733702 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 8.3 uM preincubated for 2 hrs with GSK3beta inhibitor, G1 followed by compound addition and measured after 8 hrs by Western blotting analysis (Rvb = 100 %) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4733703 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring GSK3beta protein level at 20 uM after 10 hrs by Western blotting analysis (Rvb = 100 %) | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4733704 | B | Protac activity at CRBN/GSK3beta in rat PC12 cells assessed as GSK3beta degradation by measuring reduction in GSK3beta protein level after 10 hrs by Western blotting analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature |
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