# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4826537 | B | Induction of cell membrane permeabilization in Candida albicans up to 6 times MIC by propidium iodide staining based fluorescence assay | Candida albicans | 1 | ALA4825682 | subcellular format | Scientific Literature | |
2. | ALA4826541 | B | Induction of cytoplasmic membrane depolarization in Candida albicans by diSC3(5)-dye based assay | Candida albicans | 1 | ALA4825682 | subcellular format | Scientific Literature | |
3. | ALA4826542 | B | Induction of cell membrane disruption in Candida albicans assessed as increase in protein leakage by Bradford assay | Candida albicans | 1 | ALA4825682 | subcellular format | Scientific Literature | |
4. | ALA4826543 | B | Induction of cell membrane destruction in Candida albicans assessed as reduction in LDH activity at MIC relative to control | Candida albicans | 1 | ALA4825682 | subcellular format | Scientific Literature | |
5. | ALA4826544 | B | Induction of cell membrane destruction in Candida albicans assessed as reduction in LDH activity at 4 times MIC relative to control | Candida albicans | 1 | ALA4825682 | subcellular format | Scientific Literature | |
6. | ALA4831793 | B | Disruption of Plasma membrane in Cryptococcus neoformans ATCC350 by HR-TEM analysis | Cryptococcus neoformans | 1 | ALA4831482 | cell membrane format | Scientific Literature | |
7. | ALA4831795 | B | Induction of membrane permeabilization in Cryptococcus neoformans ATCC350 assessed as increase in red fluorescence intensity at MIC measured after 1 hr by propidium iodide staining based confocal laser scanning microscopic analysis | Cryptococcus neoformans | 1 | ALA4831482 | subcellular format | Scientific Literature | |
8. | ALA4831796 | B | Induction of membrane permeabilization and disruption in Cryptococcus neoformans ATCC350 assessed as increase in green fluorescence intensity using FITC-labeled compound at MIC measured after 1 hr by confocal laser scanning microscopic analysis | Cryptococcus neoformans | 2 | ALA4831482 | subcellular format | Scientific Literature | |
9. | ALA4831798 | B | Induction of pore formation in Cryptococcus neoformans ATCC350 assessed as membrane permeabilization by measuring release of intracellular material at MIC by scanning electron microscopy | Cryptococcus neoformans | 1 | ALA4831482 | subcellular format | Scientific Literature | |
10. | ALA5030965 | B | Induction of POPS membrane destabilization in Candida albicans assessed as insertion into lipid bilayer | Candida albicans | 1 | ALA5030513 | subcellular format | Scientific Literature | |
11. | ALA5030966 | B | Induction of POPE membrane destabilization in Candida albicans assessed as insertion into lipid bilayer | Candida albicans | 1 | ALA5030513 | subcellular format | Scientific Literature | |
12. | ALA5030975 | B | Induction of POPI membrane destabilization in Candida albicans assessed as insertion into lipid bilayer | Candida albicans | 1 | ALA5030513 | subcellular format | Scientific Literature | |
13. | ALA5030979 | B | Binding affinity to POPE membrane in Candida albicans assessed as insertion into lipid bilayer | Candida albicans | 1 | ALA5030513 | subcellular format | Scientific Literature | |
14. | ALA5036209 | B | Induction of cell membrane disruption in Candida albicans ATCC14053 at 2.5 uM preincubated for 15 mins followed by irradiated with 81 J/cm^2 light for 15 mins by DAPI staining based confocal laser scanning microscopic analysis | Candida albicans | 1 | ALA5034041 | subcellular format | Scientific Literature | |
15. | ALA5036547 | B | Induction of membrane disruption in Saccharomyces cerevisiae BY4741 assessed as cell lysis by measuring increase in extracellular ATP level at pH 7.5 in presence of 2% glucose incubated for 30 mins | Saccharomyces cerevisiae BY4741 | 1 | ALA5036307 | subcellular format | Scientific Literature | |
16. | ALA5036548 | B | Induction of membrane disruption in Saccharomyces cerevisiae BY4741 assessed as cell lysis by measuring increase in extracellular ATP level at pH 7.5 in presence of 8% glucose incubated for 30 mins | Saccharomyces cerevisiae BY4741 | 1 | ALA5036307 | subcellular format | Scientific Literature | |
17. | ALA5036565 | B | Induction of membrane disruption in Saccharomyces cerevisiae BY4741 at 50 mM incubated for 2 hrs by FM4-64 staining based analysis | Saccharomyces cerevisiae BY4741 | 1 | ALA5036307 | subcellular format | Scientific Literature | |
18. | ALA5111254 | B | Induction of cell membrane disruption in Aspergillus fumigatus ATCC 46645 assessed as accumulation of cytoplasmic content at IC50 concentration by transmission electron microscopic analysis | Aspergillus fumigatus | 3 | ALA5108042 | subcellular format | Scientific Literature | |
19. | ALA5117436 | B | Induction of cell membrane damage in Candida albicans ATCC 10231 at 2 to 4 times MIC by propidium iodide staining based fluorescence assay | Candida albicans | 2 | ALA5113473 | subcellular format | Scientific Literature | |
20. | ALA5117437 | B | Induction of cell membrane damage in Candida albicans ATCC 10231 assessed as increase in protein leakage by protein leakage test | Candida albicans | 1 | ALA5113473 | subcellular format | Scientific Literature |