In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 3 mg/kg/day, po measured after 6 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 10 mg/kg/day, po measured after 6 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 30 mg/kg/day, po measured after 6 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 3 mg/kg/day, po measured after 12 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 10 mg/kg/day, po measured after 12 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 30 mg/kg/day, po measured after 12 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 20 mg/kg measured after 1 hr post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 20 mg/kg measured after 4 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 20 mg/kg measured after 12 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 20 mg/kg measured after 24 hrs post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy administered orally once daily measured after 24 hrs post-removal of spleen on day 10
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as reduction in ankle diameter administered orally once daily measured after 24 hrs post-removal of spleen on day 10
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 10 mg/kg, po qd measured after 1 hr post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 20 mg/kg, po qd measured after 1 hr post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 40 mg/kg, po qd measured after 1 hr post-removal of spleen on day 10 relative to control
In vivo inhibition of BTK in splenocytes of collagen-induced arthritis Lewis rat model assessed as target occupancy at 20 mg/kg, po bid measured after 1 hr post-removal of spleen on day 10 relative to control