# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4808136 | B | PROTAC activity at CRBN/CDK12 in human Jurkat cells assessed as induction of CDK12 degradation at 100 nM incubated for 6 hrs by western blot analysis | Homo sapiens | 10 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4808137 | B | PROTAC activity at CRBN/CDK12 in human Jurkat cells assessed as induction of CDK12 degradation up to 500 nM incubated for 6 hrs by western blot analysis | Homo sapiens | 7 | cell-based format | Patent Bioactivity Data | ||
3. | ALA4822286 | B | Protac activity at CDK12/CRBN in human HEK293 cells assessed as degradation of CDK12 at 0.01 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA4822295 | B | Protac activity at CDK12/CRBN in human HEK293 cells assessed as degradation of CDK12 at 1 uM measured upto 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4822316 | B | Protac activity at CDK12/CRBN in human HEK293 cells assessed as degradation of CDK12 at 1 uM incubated for 24 hrs in presence of MG132 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA5126113 | B | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of CDK12 degradation incubated for 15 hrs by immunoblotting analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
7. | ALA5126116 | B | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of CDK12 degradation at 1 uM incubated for 15 hrs by immunoblotting analysis relative to control | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
8. | ALA5126119 | B | Protac activity at CRBN/CDK12 in human MFM-223 cells assessed as induction of degradation by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA5126121 | B | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of degradation by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA5126123 | B | Protac activity at CRBN/CDK12 in human MFM-223 cells assessed as induction of degradation at 500 nM incubated upto 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA5126124 | B | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as induction of degradation at 500 nM incubated upto 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA5126127 | B | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as degradation of CDK12 at 500 nM measured after 6 hrs in presence of carfilzomib by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA5126129 | B | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as degradation of CDK12 at 500 nM measured after 6 hrs in presence of bafilomycin by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA5126131 | B | Protac activity at CRBN/CDK12 in human MDA-MB-231 cells assessed as inhibition of degradation of CDK12 at 500 nM measured after 6 hrs in presence of thalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature |