# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835700 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 0.1 to 1 uM incubated for 6 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4835702 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA4835704 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM incubated for 4 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA4835707 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation incubated for 12 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4835717 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM pretreated with CRBN ligand, lenalidomide for 1 hr followed by incubation with compound for 6 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4835719 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM pretreated with proteasome inhibitor, MG132 for 1 hr followed by incubation with compound for 6 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4835732 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 1 uM incubated for 6 hrs by western blot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
8. | ALA4835734 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM pretreated with MDM2 inhibitor, Ugi ligand 1 for 1 hr followed by incubation with compound for 6 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4835736 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM pretreated with MDM2 inhibitor, WB138 for 1 hr followed by incubation with compound for 6 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4835739 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 10 to 100 nM measured after 6 hrs by western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
11. | ALA4835761 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 10 nM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
12. | ALA4835762 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 100 nM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4835763 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 0.1 uM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
14. | ALA4835764 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 1 uM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
15. | ALA4835771 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by western blot analysis | Homo sapiens | 13 | cell-based format | Scientific Literature |