| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA646323 | B | Tested for its ability to inhibit rabbit liver aldehyde oxidase catalyzed oxidation of N-methyl-nicotinamide (NMN) | Oryctolagus cuniculus | 8 | assay format | Scientific Literature | ||
| 2. | ALA1640074 | A | Activity of aldehyde oxidase in human liver cytosol | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 3. | ALA1640075 | A | Activity of aldehyde oxidase in human liver cytosol assessed as enzyme activity per mg of cytosol | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA1640077 | A | Inhibition of human aldehyde oxidase | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 5. | ALA2015635 | A | Drug metabolism in human liver S9 fraction assessed as aldehyde oxidase-mediated oxidation at 10 uM after 1 hr by LC/MS analysis | Homo sapiens | 20 | subcellular format | Scientific Literature | ||
| 6. | ALA2015636 | A | Drug metabolism in human liver S9 fraction assessed as aldehyde oxidase-mediated formation of mono-oxygenated metabolite M1 at 10 uM after 1 hr by LC/MS analysis in the presence of AO inhibitor raloxifene | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 7. | ALA2015639 | A | Drug metabolism in human liver S9 fraction assessed as aldehyde oxidase-mediated oxidation to formation of mono-oxygenated metabolite M1 at 10 uM after 1 hr by LC/MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 8. | ALA2025442 | A | Metabolic stability in human cytosol assessed as aldehyde oxidase-mediated pyridine ring oxidation of compound by HPLC and LC/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3051427 | A | Inhibition of Homo sapiens (human) aldehyde oxidase | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA2346307 | A | Metabolic stability in human liver S9 fraction assessed as aldehyde-oxidase-mediated 4-hydroxy-8-(6-methoxypyridin-3-yl)-3-methyl-1-(1-methylpiperidin-4-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one formation by LC/MS analysis in absence of NADPH | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA3269091 | A | Induction of human aldehyde oxidase-mediated metabolism expressed in Escherichia coli assessed as 5-(1H-indol-7-ylamino)-7-((1R,2S)-2-aminocyclohexylamino)pyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA3537680 | A | Uncompetitive inhibition of human liver cytosolic aldehyde oxidase using phthalazine as substrate assessed as enzyme-substrate complex by Lineweaver-Burk plot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA3537681 | A | Competitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate assessed as free enzyme by Lineweaver-Burk plot analysis | Homo sapiens | 7 | tissue-based format | Scientific Literature | ||
| 14. | ALA3537682 | A | Uncompetitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate assessed as enzyme-substrate complex by Lineweaver-Burk plot analysis | Homo sapiens | 7 | tissue-based format | Scientific Literature | ||
| 15. | ALA3537683 | A | Ratio of Ki for uncompetitive inhibition of human liver cytosolic aldehyde oxidase to Ki for competitive inhibition of human liver cytosolic aldehyde oxidase | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 16. | ALA3537685 | A | Inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate by LC-MS/MS analysis relative to control | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 17. | ALA3537686 | A | Selectivity ratio Ki for uncompetitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate to Ki for uncompetitive inhibition of human liver cytosolic aldehyde oxidase using phthalazine as substrate | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 18. | ALA3540014 | A | Activity at human recombinant AO expressed in Escherichia coli cells assessed as enzyme-mediated BILR516 metabolite formation at 5 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3540015 | A | Drug metabolism in human liver cytosol assessed as aldehyde-oxidase-mediated BILR516 metabolite formation after 10 mins by Eadie-Hofstee plot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 20. | ALA3540016 | A | Drug metabolism in human liver cytosol assessed as aldehyde-oxidase-mediated BILR516 metabolite formation measured per mg protein after 10 mins by Eadie-Hofstee plot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature |
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