| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA708592 | B | Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetase | Escherichia coli | 8 | ALA1131923 | single protein format | Scientific Literature | |
| 2. | ALA853638 | B | Compound tested for the inhibition of Staphylococcus aureus Leucyl-tRNA synthetase | Staphylococcus aureus | 1 | ALA1131923 | single protein format | Scientific Literature | |
| 3. | ALA708594 | B | Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29 | Staphylococcus aureus | 4 | ALA1132771 | single protein format | Scientific Literature | |
| 4. | ALA708595 | B | Compound (10 uM) was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29; no inhibition | Staphylococcus aureus | 1 | ALA1132771 | single protein format | Scientific Literature | |
| 5. | ALA708596 | B | Compound (100 uM) was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29 | Staphylococcus aureus | 1 | ALA1132771 | single protein format | Scientific Literature | |
| 6. | ALA708597 | B | Compound (100 uM) was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29; no inhibition | Staphylococcus aureus | 5 | ALA1132771 | single protein format | Scientific Literature | |
| 7. | ALA708598 | B | Compound tested for the inhibition of human Leucyl-tRNA synthetase | 4 | ALA1131923 | single protein format | Scientific Literature | ||
| 8. | ALA885012 | F | Inhibitory activity against Echovirus 9 using plaque reduction assay | Echovirus | 3 | ALA1141044 | assay format | Scientific Literature | |
| 9. | ALA3769291 | B | Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting method in presence of ATP | Homo sapiens | 5 | ALA3763142 | single protein format | Scientific Literature | |
| 10. | ALA3813560 | B | Inhibition of leucyl-tRNA synthetase (unknown origin) expressed in HEK293 cells assessed as inhibition of leucine-induced mTORC1-mediated S6 kinase phosphorylation pre-treated at 1 mM followed by leucine stimulation for 10 mins by immunoblotting analysis | Homo sapiens | 15 | ALA3808272 | cell-based format | Scientific Literature | |
| 11. | ALA3813561 | B | Inhibition of leucyl-tRNA synthetase (unknown origin) expressed in HEK293 cells assessed as inhibition of leucine-induced mTORC1-mediated S6 kinase phosphorylation pre-treated with compound followed by leucine stimulation for 10 mins by immunoblotting analysis | Homo sapiens | 4 | ALA3808272 | cell-based format | Scientific Literature | |
| 12. | ALA3813562 | B | Inhibition of leucyl-tRNA synthetase (unknown origin) expressed in HEK293 cells assessed as inhibition of leucine-induced mTORC1-mediated S6 kinase phosphorylation pre-treated at 800 uM followed by leucine stimulation for 10 mins by immunoblotting analysis | Homo sapiens | 1 | ALA3808272 | cell-based format | Scientific Literature | |
| 13. | ALA3813563 | B | Inhibition of leucyl-tRNA synthetase (unknown origin) expressed in HEK293 cells assessed as inhibition of leucine-induced mTORC1-mediated S6 kinase phosphorylation pre-treated at 100 nM followed by leucine stimulation for 10 mins by immunoblotting analysis | Homo sapiens | 1 | ALA3808272 | cell-based format | Scientific Literature | |
| 14. | ALA3813567 | B | Inhibition of leucyl-tRNA synthetase (unknown origin) catalytic activity assessed as aminoleucylation | Homo sapiens | 2 | ALA3808272 | single protein format | Scientific Literature | |
| 15. | ALA4020313 | A | Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis | Homo sapiens | 8 | ALA4017537 | assay format | Scientific Literature | |
| 16. | ALA4020316 | A | Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine addition measured after 3 hrs by liquid scintillation counting analysis | Homo sapiens | 8 | ALA4017537 | cell-based format | Scientific Literature | |
| 17. | ALA4055900 | B | Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation at 100 nM pretreated before leucine stimulation measured after 10 mins by immunoblot analysis | Homo sapiens | 1 | ALA4052681 | cell-based format | Scientific Literature | |
| 18. | ALA4055901 | B | Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation at 200 uM pretreated before leucine stimulation measured after 10 mins by immunoblot analysis | Homo sapiens | 7 | ALA4052681 | cell-based format | Scientific Literature | |
| 19. | ALA4055902 | B | Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation pretreated before leucine stimulation measured after 10 mins by immunoblot analysis | Homo sapiens | 2 | ALA4052681 | cell-based format | Scientific Literature | |
| 20. | ALA4055903 | B | Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation at 20 to 200 uM pretreated before leucine stimulation measured after 10 mins by immunoblot analysis | Homo sapiens | 1 | ALA4052681 | cell-based format | Scientific Literature |
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