| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5160160 | B | Protac activity at VHL/SOS1 in human NCI-H358 cells assessed as SOS1 protein degradation at 0.1 uM incubated for 24 hr by Western blot analysis relative to control | Homo sapiens | 16 | ALA5154769 | cell-based format | Scientific Literature | |
| 2. | ALA5160161 | B | Protac activity at VHL/SOS1 in human NCI-H358 cells assessed as SOS1 protein degradation at 1 uM incubated for 24 hr by Western blot analysis relative to control | Homo sapiens | 16 | ALA5154769 | cell-based format | Scientific Literature | |
| 3. | ALA5160162 | B | Protac activity at VHL/SOS1 in human NCI-H358 cells assessed as SOS1 protein degradation incubated for 24 hr by Western blot analysis | Homo sapiens | 4 | ALA5154769 | cell-based format | Scientific Literature | |
| 4. | ALA5160163 | B | Protac activity at VHL/SOS1 in human NCI-H358 cells assessed as SOS1 protein degradation at 1 uM and measured after 4 to 24 hr by western blot analysis | Homo sapiens | 1 | ALA5154769 | cell-based format | Scientific Literature | |
| 5. | ALA5160164 | B | Protac activity at VHL/SOS1 in human ASPC1 cells assessed as SOS1 protein degradation at 1 uM incubated measured after 16 hr by western blot analysis | Homo sapiens | 1 | ALA5154769 | cell-based format | Scientific Literature | |
| 6. | ALA5160165 | B | Protac activity at VHL/SOS1 in human ASPC1 cells assessed as SOS1 protein degradation at 0.01 to 10 uM and measured after 24 hr by western blot analysis | Homo sapiens | 1 | ALA5154769 | cell-based format | Scientific Literature | |
| 7. | ALA5160166 | B | Protac activity at VHL/SOS1 in human NCI-H358 cells assessed as SOS1 protein degradation at 0.01 to 10 uM and measured after 24 hr by western blot analysis | Homo sapiens | 1 | ALA5154769 | cell-based format | Scientific Literature | |
| 8. | ALA5160167 | B | Protac activity at VHL/SOS1 in human NCI-H358 cells assessed as SOS1 protein degradation pretreated with VHL ligand and MG132 at 1 uM followed by compound addition and measured after 24 hr by western blot analysis | Homo sapiens | 1 | ALA5154769 | cell-based format | Scientific Literature | |
| 9. | ALA5160168 | B | Protac activity at VHL/SOS1 in human ASPC1 cells assessed as SOS1 protein degradation pretreated with VHL ligand and MG132 at 1 uM followed by compound addition and measured after 24 hr by western blot analysis | Homo sapiens | 1 | ALA5154769 | cell-based format | Scientific Literature | |
| 10. | ALA5251795 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells assessed as induction of SOS1 protein degradation at 0.1 uM incubated for 24 hrs by Immunoblot analysis relative to control | Homo sapiens | 17 | ALA5247656 | cell-based format | Scientific Literature | |
| 11. | ALA5251796 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells assessed as induction of SOS1 protein degradation at 1.0 uM incubated for 24 hrs by Immunoblot analysis relative to control | Homo sapiens | 17 | ALA5247656 | cell-based format | Scientific Literature | |
| 12. | ALA5251799 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells assessed as induction of SOS1 protein degradation incubated for 24 hrs by Immunoblot analysis | Homo sapiens | 2 | ALA5247656 | cell-based format | Scientific Literature | |
| 13. | ALA5251800 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells assessed as induction of SOS1 protein degradation by measuring maximal efficacy at 2 to 2000 nM incubated for 24 hrs by Immunoblot analysis relative to control | Homo sapiens | 7 | ALA5247656 | cell-based format | Scientific Literature | |
| 14. | ALA5251805 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as induction of SOS1 degradation upto 10 uM incubated for 24 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA5247656 | cell-based format | Scientific Literature | |
| 15. | ALA5251806 | B | PROTAC activity at VHL/SOS1 in human ASPC1 cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation upto 10 uM incubated for 24 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA5247656 | cell-based format | Scientific Literature | |
| 16. | ALA5251807 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells harboring KRAS G12C mutant with shRNA lentivirus mediated VHL knockdown assessed as induction of SOS1 degradation at 1 uM incubated for 24 hrs by Immunoblot analysis | Homo sapiens | 1 | ALA5247656 | cell-based format | Scientific Literature | |
| 17. | ALA5251808 | B | PROTAC activity at VHL/SOS1 in human ASPC1 cells harboring KRAS G12D mutant with shRNA lentivirus mediated VHL knockdown assessed as induction of SOS1 degradation at 1 uM incubated for 24 hrs by Immunoblot analysis | Homo sapiens | 1 | ALA5247656 | cell-based format | Scientific Literature | |
| 18. | ALA5251809 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as induction of SOS1 degradation at 1 uM preincubated with VHL ligand for 4 hrs followed by compound treatment and measured after 24 hrs by Immunoblot analysis | Homo sapiens | 1 | ALA5247656 | cell-based format | Scientific Literature | |
| 19. | ALA5251810 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as induction of SOS1 degradation at 1 uM preincubated with (R)-1-(4-(4-((1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)piperidin-1-yl)ethanone for 4 hrs followed by compound treatment and measured after 24 hrs by Immunoblot analysis | Homo sapiens | 1 | ALA5247656 | cell-based format | Scientific Literature | |
| 20. | ALA5251811 | B | PROTAC activity at VHL/SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as induction of SOS1 degradation at 1 uM preincubated with MG132 for 4 hrs followed by compound treatment and measured after 24 hrs by Immunoblot analysis | Homo sapiens | 1 | ALA5247656 | cell-based format | Scientific Literature |
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