Antiviral activity against Human coronavirus OC43 infected in human HRT18 cells assessed as decrease in viral load at 10 uM treated at the time of infection measured after 28 hrs by qRT-PCR analysis relative to control
Antiviral activity against Human coronavirus OC43 infected in new born C57BL/6 mouse assessed as survival rate at 15 mg/kg, sc transfered via placenta after administration to pregnant mouse
Antiviral activity against Human coronavirus OC43 infected in new born C57BL/6 mouse assessed as survival rate at 15 mg/kg, sc transfered via maternal milk after administration to pregnant mouse
Antiviral activity against Human coronavirus OC43 infected in new born C57BL/6 mouse assessed as survival rate at 5 mg/kg, sc transfered via placenta after administration to pregnant mouse
Antiviral activity against Human coronavirus OC43 infected in new born C57BL/6 mouse assessed as survival rate at 5 mg/kg, sc transfered via maternal milk after administration to pregnant mouse
Antiviral activity against Human coronavirus OC43 infected in new born C57BL/6 mouse assessed as survival rate at 1 mg/kg, sc transfered via placenta after administration to pregnant mouse
Antiviral activity against Human coronavirus OC43 infected in new born C57BL/6 mouse assessed as survival rate at 1 mg/kg, sc transfered via maternal milk after administration to pregnant mouse
Inhibition of Human coronavirus OC43 replication infected in human 293T cells transfected with wild-type HCoV-OC43 N protein assessed as M mRNA level at 10 uM by RT-PCR analysis (Rvb = 2.41 no unit)
Inhibition of Human coronavirus OC43 replication infected in human 293T cells assessed as M mRNA level at 10 uM by RT-PCR analysis (Rvb = 0.32 no unit)
Antiviral activity against wild type HCoV-OC43 infected in human Huh-7 cells preincubated for 1 hrs followed by overlaying with reduced-serum Medium and measured after 72 hrs ELISpot assay
Antiviral activity against HCoV-OC43 infected in BALB/c mouse assessed as protection against virus-induced lethal infection at 15 mg/kg, ip administered for 14 days and measured up to 20 days