| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4844074 | F | Antitumour activity against human SW620/5-FU cells xenografted in athymic nude mouse assessed as inhibition of tumour growth at 1.08 mg/kg/day, iv administered for 24 days | Homo sapiens | 1 | ALA4842358 | organism-based format | Scientific Literature | |
| 2. | ALA5099153 | F | Antitumor activity against human SW620/5-FU cells xenografted in nude mouse assessed as tumor volume at 15 mg/kg, iv administered once daily and measured on day 1 (Rvb = 105 +/- 14 mm3) | Homo sapiens | 1 | ALA5096216 | organism-based format | Scientific Literature | |
| 3. | ALA5099173 | F | Antiproliferative activity against human SW620/5-FU cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 8 | ALA5096216 | cell-based format | Scientific Literature | |
| 4. | ALA5099174 | F | Reversal of 5-FU resistance in human SW620/5-FU cells assessed as reduction in cell viability incubated for 48 hrs in presence of 5-FU by MTT assay | Homo sapiens | 8 | ALA5096216 | cell-based format | Scientific Literature | |
| 5. | ALA5099180 | F | Antiproliferative activity against human SW620/5-FU cells assessed as reduction in cell viability at 40 uM incubated for 48 hrs by MTT assay | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 6. | ALA5099192 | F | Reversal of 5-FU resistance in human SW620/5-FU cells assessed as reduction in 5-Fluorouracil IC50 at 2 uM incubated for 48 hrs (Rvb = 1547.23 +/- 68.94 %) | Homo sapiens | 2 | ALA5096216 | cell-based format | Scientific Literature | |
| 7. | ALA5099193 | F | Reversal of 5-FU resistance in human SW620/5-FU cells assessed as reduction in 5-Fluorouracil IC50 at 5 uM incubated for 48 hrs (Rvb = 1547.23 +/- 68.94 %) | Homo sapiens | 2 | ALA5096216 | cell-based format | Scientific Literature | |
| 8. | ALA5099194 | F | Reversal of 5-FU resistance in human SW620/5-FU cells assessed as fold reduction in 5-Fluorouracil IC50 at 2 uM incubated for 48 hrs | Homo sapiens | 2 | ALA5096216 | cell-based format | Scientific Literature | |
| 9. | ALA5099195 | F | Reversal of 5-FU resistance in human SW620/5-FU cells assessed as fold reduction in 5-Fluorouracil IC50 at 5 uM incubated for 48 hrs | Homo sapiens | 2 | ALA5096216 | cell-based format | Scientific Literature | |
| 10. | ALA5099205 | F | Induction of apoptosis in human SW620/5-FU cells assessed as viable cells at 10 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 94.3%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 11. | ALA5099206 | F | Induction of apoptosis in human SW620/5-FU cells at 20 to 40 uM in presence of 5-FU by Hochest33342 staining based assay | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 12. | ALA5099207 | F | Induction of apoptosis in human SW620/5-FU cells assessed as early apoptotic cells at 10 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 2.73%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 13. | ALA5099208 | F | Induction of apoptosis in human SW620/5-FU cells assessed as late apoptotic cells at 10 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 2.97%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 14. | ALA5099209 | F | Induction of apoptosis in human SW620/5-FU cells assessed as necrotic cells at 10 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 0%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 15. | ALA5099210 | F | Induction of apoptosis in human SW620/5-FU cells assessed as viable cells at 20 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 94.3%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 16. | ALA5099211 | F | Induction of apoptosis in human SW620/5-FU cells assessed as early apoptotic cells at 20 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 2.73%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 17. | ALA5099212 | F | Induction of apoptosis in human SW620/5-FU cells assessed as late apoptotic cells at 20 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 2.97%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 18. | ALA5099213 | F | Induction of apoptosis in human SW620/5-FU cells assessed as necrotic cells at 20 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 0%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 19. | ALA5099214 | F | Induction of apoptosis in human SW620/5-FU cells assessed as viable cells at 40 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 94.3%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature | |
| 20. | ALA5099215 | F | Induction of apoptosis in human SW620/5-FU cells assessed as early apoptotic cells at 40 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry assay (Rvb = 2.73%) | Homo sapiens | 1 | ALA5096216 | cell-based format | Scientific Literature |
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