| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5239318 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as protein degradation at 1 uM measured after 6 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5239319 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as ratio of protein degradation normalized to DMSO at 0.1 uM measured after 6 hrs by immunoblotting analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 3. | ALA5239320 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as ratio of protein degradation normalized to DMSO at 1 uM measured after 6 hrs by immunoblotting analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA5239321 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as ratio of protein degradation normalized to DMSO at 10 uM measured after 6 hrs by immunoblotting analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA5239322 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as protein degradation at 1 uM by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5239323 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as protein degradation at 1 uM measured after 48 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5239324 | B | PROTAC activity at SOS1/Cereblon in cycloheximide pretreated human SW620 cells assessed as protein degradation at 1 uM measured after 3 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5239325 | B | PROTAC activity at SOS1/Cereblon in BI3406 pretreated human SW620 cells assessed as protein degradation at 1 uM measured after 24 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5239326 | B | PROTAC activity at SOS1/Cereblon in lenalidomide pretreated human SW620 cells assessed as protein degradation at 1 uM measured after 24 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5239327 | B | PROTAC activity at SOS1/Cereblon in neddylation inhibitor MLN4924 pretreated human SW620 cells assessed as protein degradation at 1 uM measured after 24 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5239328 | B | PROTAC activity at SOS1/Cereblon in proteasome inhibitor MG132 pretreated human SW620 cells assessed as protein degradation at 1 uM measured after 24 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5239329 | B | PROTAC activity at SOS1/Cereblon in human HCT-116 cells assessed as protein degradation measured after 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5239330 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as protein degradation measured after 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5239331 | B | PROTAC activity at SOS1/Cereblon in human SW1417 cells assessed as protein degradation measured after 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5239332 | B | PROTAC activity at SOS1/Cereblon in human HCT116 cells assessed as protein degradation at 10 uM measured after 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5239333 | B | PROTAC activity at SOS1/Cereblon in human SW620 cells assessed as protein degradation at 10 uM measured after 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5239334 | B | PROTAC activity at SOS1/Cereblon in human SW1417 cells assessed as protein degradation at 10 uM measured after 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5239337 | B | PROTAC activity at SOS1/Cereblon in patient-derived CRC organoid MCC19990-010 harboring KRAS G12A mutation assessed as necrosis at 1 uM measured after 24 hrs by hematoxylin and eosin staining based immunohistochemistry | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 19. | ALA5239338 | B | PROTAC activity at SOS1/Cereblon in patient-derived CRC organoid MCC19990-013 harboring KRAS G12A mutation assessed as necrosis at 1 uM measured after 24 hrs by hematoxylin and eosin staining based immunohistochemistry | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 20. | ALA5239340 | B | PROTAC activity at SOS1/Cereblon in patient-derived CRC organoid MCC19990-002 harboring KRAS G12A mutation assessed as necrosis at 1 uM measured after 24 hrs by hematoxylin and eosin staining based immunohistochemistry | Homo sapiens | 1 | tissue-based format | Scientific Literature |
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