| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4119284 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced superoxide anion generation preincubated for 5 mins followed by CB stimulation for 3 mins and subsequent fMLF stimulation for 10 mins by spectrophotometric method | Homo sapiens | 2 | ALA4118039 | cell-based format | Scientific Literature | |
| 2. | ALA4119285 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate preincubated for 5 mins followed by CB/fMLF stimulation | Homo sapiens | 7 | ALA4118039 | cell-based format | Scientific Literature | |
| 3. | ALA4119286 | A | Proinflammatory activity in human neutrophils assessed as superoxide anion generation at 10 uM incubated for 5 mins by spectrophotometric method relative to control | Homo sapiens | 7 | ALA4118039 | cell-based format | Scientific Literature | |
| 4. | ALA4119287 | A | Proinflammatory activity in human neutrophils assessed as elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate incubated for 5 mins relative to control | Homo sapiens | 3 | ALA4118039 | cell-based format | Scientific Literature | |
| 5. | ALA4119288 | A | Proinflammatory activity in human neutrophils assessed as superoxide anion generation at 10 uM preincubated for 5 mins followed by CB addition measured after 3 mins by spectrophotometric method relative to control | Homo sapiens | 1 | ALA4118039 | cell-based format | Scientific Literature | |
| 6. | ALA4132018 | F | Anti inflammatory activity in human neuterophils preincubated for 10 mins followed by zymosan activated serum addition measured for 30 mins | Homo sapiens | 2 | ALA4130365 | cell-based format | Scientific Literature | |
| 7. | ALA4144597 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase inhibitable reduction of ferricytochrome c based spectrophotometric assay | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 8. | ALA4144598 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation at 10 uM pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase inhibitable reduction of ferricytochrome c based spectrophotometric assay relative to control | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 9. | ALA4144599 | F | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 10. | ALA4144600 | F | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release at 10 uM pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate relative to control | Homo sapiens | 4 | ALA4138279 | cell-based format | Scientific Literature | |
| 11. | ALA4150868 | F | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation preincubated for 5 mins followed by cytochalasin B/fMLP addition for 3 mins by superoxide dismutase inhibitable reduction of ferricytochrome c based assay | Homo sapiens | 6 | ALA4145645 | cell-based format | Scientific Literature | |
| 12. | ALA4150869 | F | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release preincubated for 5 mins followed by fMLP/CB stimulation and measured for 10 mins using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate | Homo sapiens | 6 | ALA4145645 | cell-based format | Scientific Literature | |
| 13. | ALA4152407 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation | Homo sapiens | 1 | ALA4152182 | cell-based format | Scientific Literature | |
| 14. | ALA4178693 | F | Inhibition of fMLP/CB-induced superoxide anion production in human neutrophils assessed as SOD-based ferricytochrome c reduction assay | Homo sapiens | 5 | ALA4177557 | cell-based format | Scientific Literature | |
| 15. | ALA4178694 | F | Inhibition of fMLP/CB-induced elastase release in human neutrophils | Homo sapiens | 5 | ALA4177557 | cell-based format | Scientific Literature | |
| 16. | ALA4178695 | F | Inhibition of fMLP-induced intracellular Ca2+ ion mobilization in human neutrophils assessed as peak Ca2+ level at 10 uM pre-incubated for 5 mins before fMLP stimulation by spectrofluorometry (Rvb = 389.51 +/- 15.85 nM) | Homo sapiens | 1 | ALA4177557 | cell-based format | Scientific Literature | |
| 17. | ALA4178696 | F | Inhibition of fMLP-induced intracellular Ca2+ ion mobilization in human neutrophils assessed as time taken to reduce to half of Ca2+ ion mobilization peak values at 10 uM pre-incubated for 5 mins before fMLP stimulation by spectrofluorometry (Rvb = 24.75 +/- 2.81 secs) | Homo sapiens | 1 | ALA4177557 | cell-based format | Scientific Literature | |
| 18. | ALA4185177 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins by spectrophotometry | Homo sapiens | 28 | ALA4184133 | cell-based format | Scientific Literature | |
| 19. | ALA4185178 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate | Homo sapiens | 28 | ALA4184133 | cell-based format | Scientific Literature | |
| 20. | ALA4185179 | F | Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction at 10 ug/ml incubated for 5 mins before fMLP/CB stimulation for 3 mins by spectrophotometry | Homo sapiens | 11 | ALA4184133 | cell-based format | Scientific Literature |
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