| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA813829 | B | Inhibition of T-cell Protein Tyrosine Phosphatase (TCPTP) | Homo sapiens | 13 | single protein format | Scientific Literature | ||
| 2. | ALA2114891 | F | PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in a fluorescence-based, Lymphoid Phosphatase (PTPN22, LYP-1) selectivity Assay. (Class of assay: confirmatory) | Homo sapiens | 71 | assay format | PubChem BioAssays | ||
| 3. | ALA1804672 | B | Inhibition of LYP at 100 uM | 1 | single protein format | Scientific Literature | |||
| 4. | ALA1664624 | B | Inhibition of recombinant LyP assessed as hydrolysis of DiFMUP | 35 | single protein format | Scientific Literature | |||
| 5. | ALA1664625 | B | Inhibition of LyP in human Jurkat TAg T cells co-expressing proximal IL-2 promoter assessed as increase of TCR-induced NFAT/AP1 activation at 5 uM after 45 mins by luciferase assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 6. | ALA1664626 | B | Inhibition of LyP in human Jurkat TAg T cells co-expressing proximal IL-2 promoter assessed as increase of TCR-induced NFAT/AP1 activation after 45 mins by luciferase assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA1664627 | B | Inhibition of LyP in human Jurkat TAg T cells co-expressing proximal IL-2 promoter assessed as increase of TCR-induced NFAT/AP1 activation at 0.1 to 30 uM after 45 mins by luciferase assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA1664670 | B | Inhibition of LyP in human Jurkat TAg T cells co-expressing proximal IL-2 promoter assessed as increase of TCR-induced NFAT/AP1 activation at >= 3 uM after 45 mins by luciferase assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA1664671 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced Lck-pY394 phosphorylation at 3 uM after 45 mins by immunoblotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA1664672 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced Lck-pY394 phosphorylation at 5 uM after 45 mins by immunoblotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA1664673 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced Lck-pY394 phosphorylation at 10 uM after 45 mins by immunoblotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA1664674 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced Lck-pY394 phosphorylation at 30 uM after 45 mins by immunoblotting | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA1664675 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced ITAM zeta phosphorylation at 3 uM after 45 mins by immunoblotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA1664676 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced ITAM zeta phosphorylation at 5 uM after 45 mins by immunoblotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA1664677 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced ITAM zeta phosphorylation at 10 uM after 45 mins by immunoblotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA1664678 | B | Inhibition of LyP in human Jurkat TAg T cells assessed as inhibition of TCR-induced ITAM zeta phosphorylation at 30 uM after 45 mins by immunoblotting | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA2015670 | B | Inhibition of Lyp-mediated pNPP hydrolysis | 1 | single protein format | Scientific Literature | |||
| 18. | ALA2114828 | F | PubChem BioAssay. Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the Lymphoid Phosphatase (PTPN22) Inhibition Assay. (Class of assay: confirmatory) | Homo sapiens | 92 | assay format | PubChem BioAssays | ||
| 19. | ALA2161820 | B | Inhibition of LYP-mediated TCR signaling in C305 antibody stimulated human Jurkat T cells expressing SV40 large T antigen assessed as increase in pSRC Y416 dephosphorylation at 50 uM by Western blotting relative to untreated control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 20. | ALA2161821 | B | Inhibition of LYP expressed in Escherichia coli BL21 using ARLIED-NEpYTAREG substrate | 5 | assay format | Scientific Literature |
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