# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1070026 | Binding | Inhibition of SHP2-dependent ERK1/2 activation in EGF-stimulated mouse NIH/3T3 cells assessed as phosphorylated ERK1/2 level at 10 uM treated for 3 hrs before EGF challenge measured after 60 mins of EGF stimulation by immunoblot analysis | Mus musculus | 1 | ALA1157613 | cell-based format | Scientific Literature | |
2. | ALA1070027 | Binding | Inhibition of SHP2-dependent ERK1/2 activation in EGF-stimulated mouse NIH/3T3 cells assessed as phosphorylated ERK1/2 level at 10 uM treated for 3 hrs before EGF challenge measured after 5 to 15 mins of EGF stimulation by immunoblot analysis | Mus musculus | 1 | ALA1157613 | cell-based format | Scientific Literature | |
3. | ALA814613 | Binding | Percent inhibition of Tyrosine phosphatase SHP2 SH2 domain containing PTP involved in insulin uM | 66 | ALA1135703 | single protein format | Scientific Literature | ||
4. | ALA814614 | Binding | Percent inhibition of Tyrosine phosphatase SHP2 SH2 domain containing PTP involved in insulin uM | Mus musculus | 2 | ALA1135703 | single protein format | Scientific Literature | |
5. | ALA995827 | Binding | Inhibition of EGF-induced SHP2 activation in mouse embryonic fibroblasts by immunocomplex phosphatase assay | Mus musculus | 2 | ALA1140228 | single protein format | Scientific Literature | |
6. | ALA995828 | Binding | Inhibition of EGF-induced SHP2 D61G mutant activation in mouse embryonic fibroblasts by immunocomplex phosphatase assay | Mus musculus | 2 | ALA1140228 | assay format | Scientific Literature | |
7. | ALA995829 | Binding | Inhibition of SHP2 assessed as blockade of IL3-induced ERK1/ERK2 activation in mouse Ba/F3 cells by immunoblotting | Mus musculus | 2 | ALA1140228 | cell-based format | Scientific Literature | |
8. | ALA2434681 | Binding | Inhibition of IL3-induced SHP2-Gab2 interaction in mouse Ba/F3 cells pretreated at 30 uM for 3 hrs prior IL3 stimulation by immunoblotting method | Mus musculus | 1 | ALA2429837 | cell-based format | Scientific Literature | |
9. | ALA2434682 | Binding | Inhibition of SHP2-mediated stat5 phosphorylation in IL3-stimulated mouse Ba/F3 cells pretreated for 3 hrs prior IL3 stimulation by immunoblotting method | Mus musculus | 1 | ALA2429837 | cell-based format | Scientific Literature | |
10. | ALA2434683 | Binding | Inhibition of SHP2-mediated Jak2 phosphorylation in IL3-stimulated mouse Ba/F3 cells pretreated for 3 hrs prior IL3 stimulation by immunoblotting method | Mus musculus | 1 | ALA2429837 | cell-based format | Scientific Literature | |
11. | ALA2434684 | Binding | Inhibition of SHP2-mediated Akt phosphorylation in IL3-stimulated mouse Ba/F3 cells pretreated for 3 hrs prior IL3 stimulation by immunoblotting method | Mus musculus | 1 | ALA2429837 | cell-based format | Scientific Literature | |
12. | ALA2434685 | Binding | Inhibition of SHP2-mediated ERK1/2 phosphorylation in IL3-stimulated mouse Ba/F3 cells pretreated for 3 hrs prior IL3 stimulation by immunoblotting method | Mus musculus | 1 | ALA2429837 | cell-based format | Scientific Literature | |
13. | ALA4422860 | Binding | Inhibition of SHP2 in mouse Ba/F3 cells assessed as reduction in IL3-stimulated ERK phosphorylation pretreated for 4 hrs followed by IL3 stimulation and measured after 5 to 60 mins by Western blot analysis | Mus musculus | 1 | ALA4422612 | cell-based format | Scientific Literature | |
14. | ALA4422862 | Binding | Inhibition of SHP2 in mouse Ba/F3 cells assessed as reduction in IL3-stimulated AKT phosphorylation pretreated for 4 hrs followed by IL3 stimulation and measured after 5 to 60 mins by Western blot analysis | Mus musculus | 1 | ALA4422612 | cell-based format | Scientific Literature | |
15. | ALA4422863 | Binding | Inhibition of SHP2 in mouse Ba/F3 cells assessed as reduction in IL3-stimulated JAK2 phosphorylation pretreated for 4 hrs followed by IL3 stimulation and measured after 5 to 60 mins by Western blot analysis | Mus musculus | 1 | ALA4422612 | cell-based format | Scientific Literature | |
16. | ALA4422864 | Binding | Inhibition of SHP2 in mouse Ba/F3 cells assessed as reduction in IL3-stimulated STAT5 phosphorylation pretreated for 4 hrs followed by IL3 stimulation and measured after 5 to 60 mins by Western blot analysis | Mus musculus | 1 | ALA4422612 | cell-based format | Scientific Literature | |
17. | ALA4422865 | Binding | Inhibition of PTPN11 E76K mutant in mouse embryonic fibroblasts assessed as inhibition of cell growth at 6 uM after 24 to 72 hrs by cell proliferation-based assay | Mus musculus | 1 | ALA4422612 | single protein format | Scientific Literature | |
18. | ALA4422878 | Binding | Inhibition of Ptpn11 E76K mutant in in Ptpn11 E76K mutant /Mx1-Cre containing mouse bone marrow cells assessed as reduction in GM-CSF-induced colony forming units at 1.25 to 5 uM after 7 days by inverted microscopy | Mus musculus | 1 | ALA4422612 | assay format | Scientific Literature | |
19. | ALA4422885 | Binding | Inhibition of PTPN11 in PTPN11-expressing mouse embryonic fibroblasts assessed as inhibition of cell growth at 6 uM after 24 to 72 hrs by cell proliferation-based assay | Mus musculus | 1 | ALA4422612 | single protein format | Scientific Literature | |
20. | ALA5096991 | Binding | Inhibition of SHP2 in mouse EMT6 cells harboring SOS1 mutation | Mus musculus | 1 | ALA5096160 | cell-based format | Scientific Literature |