| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA931273 | B | Inhibition of Nav1.8 channel in rat dorsal root ganglion neurons assessed as blockade of TTX-R current by patch clamp method | Rattus norvegicus | 2 | ALA1142222 | tissue-based format | Scientific Literature | |
| 2. | ALA931269 | B | Inhibition of Nav1.8 channel in rat dorsal root ganglion neurons assessed as blockade of TTX-R current at -100 mV by patch clamp method | Rattus norvegicus | 1 | ALA1142222 | tissue-based format | Scientific Literature | |
| 3. | ALA923703 | B | Inhibition of recombinant rat Nav1.8 sodium channel assessed as blockade of TTXR current by patch clamp method | Rattus norvegicus | 1 | ALA1142222 | assay format | Scientific Literature | |
| 4. | ALA987866 | B | Inhibition of rat Nav1.8 channel expressed in Xenopus oocytes coexpressing Nav1.8 beta subunit at 5 uM by whole cell voltage clamp technique | Rattus norvegicus | 1 | ALA1156508 | cell-based format | Scientific Literature | |
| 5. | ALA953996 | B | Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current at 0.3 uM by whole cell patch clamp technique | Rattus norvegicus | 6 | ALA1150418 | tissue-based format | Scientific Literature | |
| 6. | ALA953997 | B | Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current at 3 uM by whole cell patch clamp technique | Rattus norvegicus | 1 | ALA1150418 | tissue-based format | Scientific Literature | |
| 7. | ALA953998 | B | Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current at 0.1 uM by whole cell patch clamp technique | Rattus norvegicus | 2 | ALA1150418 | tissue-based format | Scientific Literature | |
| 8. | ALA953999 | B | Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current at 0.03 uM by whole cell patch clamp technique | Rattus norvegicus | 1 | ALA1150418 | tissue-based format | Scientific Literature | |
| 9. | ALA954000 | B | Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current at 1 uM by whole cell patch clamp technique | Rattus norvegicus | 4 | ALA1150418 | tissue-based format | Scientific Literature | |
| 10. | ALA954006 | B | Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp technique | Rattus norvegicus | 5 | ALA1150418 | tissue-based format | Scientific Literature | |
| 11. | ALA957288 | B | Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current at 10 uM by whole cell patch clamp technique | Rattus norvegicus | 1 | ALA1150418 | tissue-based format | Scientific Literature | |
| 12. | ALA1272890 | B | Inhibition of tetrodotoxin-resistant NaV1.8 in rat DRG neuron by electrophysiology | Rattus norvegicus | 26 | ALA1268885 | assay format | Scientific Literature | |
| 13. | ALA1286450 | B | Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiology assay | Rattus norvegicus | 19 | ALA1275385 | tissue-based format | Scientific Literature | |
| 14. | ALA1816266 | B | Inhibition of 20% inactivated TTX-resistant rat sodium channel Nav1.8 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological assay | Rattus norvegicus | 1 | ALA1811851 | cell-based format | Scientific Literature | |
| 15. | ALA2328116 | B | Binding affinity to voltage-gated Na channel 1.8 in Sprague-Dawley rat L4/L5 DRG neurons by patch-clamp technique | Rattus norvegicus | 1 | ALA2321869 | single protein format | Scientific Literature | |
| 16. | ALA3706105 | B | Electrophysiology Assay: Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons were isolated from the dorsal root ganglions and maintained in culture for 2 to 10 days in the presence of NGF (50 ng/ml) (culture media consisted of NeurobasalA supplemented with B27, glutamine and antibiotics). Small diameter neurons (nociceptors, 8-12 μm in diameter) were visually identified and probed with fine tip glass electrodes connected to an amplifier (Axon Instruments). The voltage clamp mode was used to assess the compound's IC50 holding the cells at −60 mV. In addition, the current clamp mode was employed to test the efficacy of the compounds in blocking action potential generation in response to current injections. The results of these experiments contributed to the definition of the efficacy profile of the compounds. | 74 | ALA3638418 | tissue-based format | BindingDB Database | ||
| 17. | ALA3706351 | B | Electrophysiology Assay: Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons were isolated from the dorsal root ganglions and maintained in culture for 2 to 10 days in the presence of NGF (50 ng/ml) (culture media consisted of NeurobasalA supplemented with B27, glutamine and antibiotics). Small diameter neurons (nociceptors, 8-12 μm in diameter) were visually identified and probed with fine tip glass electrodes connected to an amplifier (Axon Instruments). The voltage clamp mode was used to assess the compound's IC50 holding the cells at −60 mV. In addition, the current clamp mode was employed to test the efficacy of the compounds in blocking action potential generation in response to current injections. | 157 | ALA3638518 | tissue-based format | BindingDB Database | ||
| 18. | ALA3880179 | B | Inhibition of rat NaV1.8 | Rattus norvegicus | 1 | ALA3879903 | single protein format | Patent Bioactivity Data | |
| 19. | ALA3887284 | B | Electrophysiology Assay: Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons were isolated from the dorsal root ganglions and maintained in culture for 2 to 10 days in the presence of NGF (50 ng/ml) (culture media consisted of NeurobasalA supplemented with B27, glutamine and antibiotics). Small diameter neurons (nociceptors, 8-12 um in diameter) were visually identified and probed with fine tip glass electrodes connected to an amplifier (Axon Instruments). The "voltage clamp" mode was used to assess the compound's IC50 holding the cells at -60 mV. In addition, the "current clamp" mode was employed to test the efficacy of the compounds in blocking action potential generation in response to current injections. | 80 | ALA3886257 | assay format | BindingDB Database | ||
| 20. | ALA3887400 | B | Electrophysiology Assay: Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons were isolated from the dorsal root ganglions and maintained in culture for 2 to 10 days in the presence of NGF (50 ng/ml) (culture media consisted of NeurobasalA supplemented with B27, glutamine and antibiotics). Small diameter neurons (nociceptors, 8-12 um in diameter) were visually identified and probed with fine tip glass electrodes connected to an amplifier (Axon Instruments). The voltage clamp mode was used to assess the compound's IC50 holding the cells at -60 mV. In addition, the current clamp mode was employed to test the efficacy of the compounds in blocking action potential generation in response to current injections. | 24 | ALA3886307 | assay format | BindingDB Database |
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