# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA748618 | F | Compound is screened in AP1 cells expressing human NHE-3 for sodium hydrogen exchange activity | 3 | ALA1134619 | cell-based format | Scientific Literature | ||
2. | ALA2173336 | B | Inhibition of NHE3 transfected in Chinese hamster PS120 assessed as intracellular pH change up to 16 uM | 2 | ALA2169836 | cell-based format | Scientific Literature | ||
3. | ALA3861031 | B | Inhibition of human NHE3 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assay | Homo sapiens | 67 | ALA3860060 | cell-based format | Scientific Literature | |
4. | ALA3881394 | B | Inhibition of human NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated in NH4Cl-HEPES buffer containing BCECF-AM dye followed by washout with ammonium free HEPES and subsequent addition of compound in presence of NHE1 antagonist EIPA by fluorescence assay | Homo sapiens | 162 | ALA3880442 | cell-based format | Patent Bioactivity Data | |
5. | ALA3881404 | B | Inhibition of human NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated for 60 mins in NaCl-HEPES buffer followed by compound washout with NH4Cl-HEPES buffer containing BCECF-AM dye and subsequent washout with Na+ free HEPES buffer by fluorescence analysis | Homo sapiens | 5 | ALA3880442 | cell-based format | Patent Bioactivity Data | |
6. | ALA3881454 | B | Inhibition of human NHE3 expressed in chinese hamster AP1 cells preincubated for 7.5 mins followed by addition of NaCl measured after 5 mins by BACEF-AM dye based fluorescence analysis | Homo sapiens | 2 | ALA3880442 | cell-based format | Patent Bioactivity Data | |
7. | ALA3881458 | B | Inhibition of human NHE3 expressed in CHO-K1 cells assessed as inhibition of Na+/Ca+ exchange activity measured after 5 mins by BACEF-AM dye based fluorescence analysis | Homo sapiens | 1 | ALA3880442 | cell-based format | Patent Bioactivity Data | |
8. | ALA3881461 | B | Inhibition of human NHE3 expressed in chinese hamster LAP1 cells assessed as reduction in pHi recovery measured for 400 secs by BACEF-AM dye based fluorescence analysis | Homo sapiens | 4 | ALA3880442 | cell-based format | Patent Bioactivity Data | |
9. | ALA3882221 | B | Inhibition of NHE-3 (unknown origin) | Homo sapiens | 7 | ALA3881530 | single protein format | Patent Bioactivity Data | |
10. | ALA4257110 | B | Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport in presence of NHE1 inhibitor EIPA by BCECF-AM dye based fluorescence assay | Homo sapiens | 169 | ALA4257082 | cell-based format | Patent Bioactivity Data | |
11. | ALA4257133 | B | Inhibition of NHE3 (unknown origin) | Homo sapiens | 7 | ALA4257082 | single protein format | Patent Bioactivity Data | |
12. | ALA4257142 | B | Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport co-treated with NaCl-HEPES buffer for 60 mins followed by compound washout and subsequent incubation for 30 mins in presence of NaCl-HEPES buffer by BCECF-AM dye based fluorescence assay | Homo sapiens | 5 | ALA4257082 | cell-based format | Patent Bioactivity Data | |
13. | ALA4882308 | B | pHi change assay with SLC9A3 | Homo sapiens | 2 | ALA4507279 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
14. | ALA5149726 | B | Inhibition of human NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ethyl isopropyl amiloride by BCECF-AM dye based fluorescence assay | Homo sapiens | 46 | ALA5143744 | cell-based format | Scientific Literature | |
15. | ALA5258585 | B | Inhibition of human NHE3 | Homo sapiens | 1 | ALA5257060 | single protein format | Scientific Literature |