# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA985175 | B | Inhibition of rat Nav1.4 channel expressed in Xenopus oocytes by whole cell voltage clamp technique | Rattus norvegicus | 1 | ALA1156508 | cell-based format | Scientific Literature | |
2. | ALA985179 | B | Inhibition of rat Nav1.4 channel expressed in Xenopus oocyte at 1 uM by whole cell voltage clamp technique | Rattus norvegicus | 16 | ALA1156508 | assay format | Scientific Literature | |
3. | ALA1918330 | B | Inhibition of rat Nav1.4 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at holding potential of -100 mV by two-electrode voltage-clamp electrophysiology | Rattus norvegicus | 2 | ALA1914383 | cell-based format | Scientific Literature | |
4. | ALA1918336 | B | Inhibition of rat Nav1.4 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at 100 uM and at holding potential of -100 mV by two-electrode voltage-clamp electrophysiology | Rattus norvegicus | 6 | ALA1914383 | cell-based format | Scientific Literature | |
5. | ALA1918603 | B | Inhibition of rat Nav1.4 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at 300 uM and at holding potential of -100 mV by two-electrode voltage-clamp electrophysiology | Rattus norvegicus | 1 | ALA1914383 | cell-based format | Scientific Literature | |
6. | ALA3618948 | B | Inhibition of rat NaV1.4 channel at 1 uM relative to control | Rattus norvegicus | 1 | ALA3616397 | single protein format | Scientific Literature | |
7. | ALA3887129 | B | Binding Assay: In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the nitrogen. Two mutant channels were also constructed by site-directed mutagenesis. The β-STXo1 data points were collected to demonstrate that STX and its derivatives were oriented similarly within the channel pore. The similar reductions in affinity for STX to β-STXo1 and for cyclohexyl STX to cyclohexyl β-STXo1 provide strong initial evidence that the two molecules both reside in a similar orientation in the channel pore. | 11 | ALA3886174 | single protein format | BindingDB Database | ||
8. | ALA4119303 | B | Inhibition of rat Nav1.4 expressed in HEK293 cells at 10 uM after 5.5 mins by SBFI dye based fluorescence assay | Rattus norvegicus | 1 | ALA4118043 | cell-based format | Scientific Literature | |
9. | ALA4181849 | B | Inhibition of rat skeletal muscle Nav1.4 expressed in HEK293 cells by whole cell voltage clamp method | Rattus norvegicus | 1 | ALA4177680 | cell-based format | Scientific Literature | |
10. | ALA4381882 | B | Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assay | Rattus norvegicus | 4 | ALA4376895 | cell-based format | Scientific Literature | |
11. | ALA5037533 | B | Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-electrode voltage clamp assay | Rattus norvegicus | 7 | ALA5036335 | cell-based format | Scientific Literature | |
12. | ALA5125244 | B | Effect on rat Nav1.4 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology | Rattus norvegicus | 1 | ALA5120921 | cell-based format | Scientific Literature | |
13. | ALA5131295 | B | Inhibition of recombinant rat Nav1.4 expressed in CHO cells by whole cell voltage clamp electrophysiology recording | Rattus norvegicus | 1 | ALA5126674 | cell-based format | Scientific Literature |