Activity of SSAT in human DU145 cells assessed per ug DNA at 100 uM after 72 hrs in presence of serum amine oxidase inhibitor aminoguanidine (RVb = 62 +/- 4 pmol/h per ug DNA)
Activity of SSAT in human DU145 cells assessed per ug DNA at 100 uM after 48 hrs in presence of serum amine oxidase inhibitor aminoguanidine (RVb = 58 pmol/h per ug DNA)
Activity of SSAT in human DU145 cells assessed per ug DNA at 100 uM after 24 hrs in presence of serum amine oxidase inhibitor aminoguanidine (RVb = 59 +/- 1 pmol/h per ug DNA)
Drug level in human HepG2 cells assessed as SSAT1-mediated compound formation treated with SpmTrien at 100 uM for 24 hrs pretreated with 50 uM DENSpm for 24 hrs
Drug metabolism in human HepG2 cells assessed as SSAT1-mediated (N12-acetyl)-1,12-diamino-3,6,9-triazadodecane formation at 100 uM for 24 hrs pretreated with 50 uM DENSpm for 24 hrs
Drug metabolism in human HepG2 cells assessed as SSAT1-mediated (N1-acetyl)-1,12-diamino-3,6,9-triazadodecane formation at 100 uM for 24 hrs in presence of SSAT2 shRNA
Drug metabolism in human HepG2 cells assessed as SSAT1-mediated (N1-acetyl)-1,12-diamino-3,6,9-triazadodecane formation at 100 uM for 24 hrs pretreated with 50 uM DENSpm for 24 hrs