| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA816283 | B | Binding affinity against human UDP Glucuronosyltransferase 1A4 (UGT1A4) | 24 | ALA1136774 | single protein format | Scientific Literature | ||
| 2. | ALA1743326 | A | Substrate of human UDP-glucuronosyltransferase UGT1A4 | Homo sapiens | 5 | ALA1743201 | single protein format | Scientific Literature | |
| 3. | ALA1908082 | A | Specific activity of expressed human recombinant UGT1A4 | Homo sapiens | 165 | ALA1907987 | single protein format | Scientific Literature | |
| 4. | ALA1908116 | B | Drug glucuronidation reaction catalyzed by human recombinant UGT1A4 | Homo sapiens | 10 | ALA1908105 | single protein format | Scientific Literature | |
| 5. | ALA2046058 | A | Activity at UGT1A4 in human liver microsomes at 50 uM incubated for 3 mins prior to NADPH-addition measured up to 120 mins by HPLC/UV analysis | Homo sapiens | 1 | ALA2040715 | microsome format | Scientific Literature | |
| 6. | ALA3398973 | A | Drug metabolism assessed as UGT1A4-mediated compound glucuronidation in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 2 | ALA3397011 | assay format | Scientific Literature | |
| 7. | ALA3398978 | A | Activation of UGT1A4 in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 1 | ALA3397011 | assay format | Scientific Literature | |
| 8. | ALA3399064 | A | Inhibition of of UGT1A4 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC method | Homo sapiens | 1 | ALA3397011 | assay format | Scientific Literature | |
| 9. | ALA3399068 | A | Activation of UGT1A4 in pooled mixed-gender human liver microsomes at 100 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 1 | ALA3397011 | assay format | Scientific Literature | |
| 10. | ALA3537956 | A | Drug metabolism assessed as UGT1A4 activity in human liver microsome assessed as of N-glucuronidation at 25 to 200 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | microsome format | Scientific Literature | |
| 11. | ALA3537959 | A | Drug metabolism assessed as recombinant human UGT1A4 assessed as O-glucuronidation at 25 to 200 uM incubated for 60 mins by LC-MS/MS analysis in presence of 10 uM hecogenin relative to control | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 12. | ALA3541111 | A | Activity of human UGT1A4 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)-2,4-dioxothiazolidin-3-yl)tetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 13. | ALA3540223 | A | Drug metabolism assessed as recombinant human UGT1A4 assessed as velocity of O-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 14. | ALA3540224 | A | Drug metabolism assessed as recombinant human UGT1A4 assessed as velocity of N-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 15. | ALA3540228 | A | Drug metabolism assessed as recombinant human UGT1A4 assessed as O-glucuronidation at 10 to 400 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 16. | ALA3540229 | A | Drug metabolism assessed as recombinant human UGT1A4 assessed as O-glucuronidation measured per mg of protein at 10 to 400 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 17. | ALA3540230 | A | Intrinsic clearance in recombinant human UGT1A4 measured per mg of protein at 10 to 400 uM by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 18. | ALA3537738 | A | Drug metabolism assessed as human recombinant UGT1A4-mediated compound formation treated with AMG 853 at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526017 | single protein format | Scientific Literature | |
| 19. | ALA3541848 | A | Drug metabolism assessed as UDPGA-fortified human recombinant UGT1A4-mediated DTG glucuronide metabolite ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation at 16 uM after 120 mins by radio-HPLC analysis | Homo sapiens | 1 | ALA3526034 | single protein format | Scientific Literature | |
| 20. | ALA3537404 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT1A4-mediated 17-epiestriol-16-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 1 | ALA3525985 | single protein format | Scientific Literature |
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