| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3423878 | ADME | Inhibition of recombinant human CYP2C19 assessed as remaining activity at 10 uM preincubated for 5 mins followed by substrate and NADP addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 5 | ALA3421577 | single protein format | Scientific Literature | |
| 2. | ALA3425004 | ADME | Inhibition of CYP2C19 (unknown origin) by luciferase reporter assay in presence of NADPH regeneration system | Homo sapiens | 17 | ALA3421625 | single protein format | Scientific Literature | |
| 3. | ALA3429788 | ADME | Inhibition of CYP2C19 (unknown origin) at 600 nM | Homo sapiens | 1 | ALA3425497 | single protein format | Scientific Literature | |
| 4. | ALA3430123 | ADME | Inhibition of CYP2C19 (unknown origin) at 5 uM | Homo sapiens | 1 | ALA3425427 | single protein format | Scientific Literature | |
| 5. | ALA3509379 | ADME | Inhibition of CYP2C19 in human liver microsomes from 10 healthy donors at 200 uM aliskiren (SPP100) | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 6. | ALA3508956 | ADME | Inhibitory activity of 20 uM SPP100 on 1174 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 7. | ALA3508957 | ADME | Inhibitory activity of 20 uM SPP100 on 1131 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 8. | ALA3508958 | ADME | Inhibitory activity of 20 uM SPP100 on 1214 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 9. | ALA3508959 | ADME | Inhibitory activity of 200 uM SPP100 on 1375 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 10. | ALA3508960 | ADME | Inhibitory activity of 200 uM SPP100 on 1156 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 11. | ALA3508961 | ADME | Inhibitory activity of 200 uM SPP100 on 1077 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 12. | ALA3508962 | ADME | Inhibitory activity of 100 uM tranylcypromine on 49 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 13. | ALA3508963 | ADME | Inhibitory activity of 100 uM tranylcypromine on 15 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 14. | ALA3508964 | ADME | Inhibitory activity of 100 uM tranylcypromine on 34 Pmoles of cDNA-derived CYP2C19 enzyme in microsome prepared from human lymphoblastoid cell line | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 15. | ALA3537996 | ADME | Activity of human recombinant CYP2C19 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 16. | ALA3538006 | ADME | Activity of human recombinant CYP2C19 assessed as enzyme-mediated drug metabolism treated with 10 uM [14C]vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 17. | ALA3538016 | ADME | Activity of human recombinant CYP2C19 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526033 | single protein format | Scientific Literature | |
| 18. | ALA3540197 | ADME | Activity of human recombinant CYP2C19.18 mutant expressed in Saccharomyces cerevisiae BJ5457 assessed as S-mephenytoin 4'-hydroxylation per pmol protein at 200 uM after 60 mins | Homo sapiens | 1 | ALA3526057 | assay format | Scientific Literature | |
| 19. | ALA3540198 | ADME | Activity of human recombinant CYP2C19.19 mutant expressed in Saccharomyces cerevisiae BJ5457 assessed as S-mephenytoin 4'-hydroxylation per pmol protein at 200 uM after 60 mins | Homo sapiens | 1 | ALA3526057 | assay format | Scientific Literature | |
| 20. | ALA3540199 | ADME | Activity of human recombinant CYP2C19 E92D mutant expressed in Saccharomyces cerevisiae BJ5457 assessed as S-mephenytoin 4'-hydroxylation per pmol protein at 200 uM after 60 mins | Homo sapiens | 1 | ALA3526057 | assay format | Scientific Literature |
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