# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA879748 | Binding | Concentration for half maximal activation of metabotropic glutamate mGluR7 in rat | 5 | ALA1128305 | assay format | Scientific Literature | ||
2. | ALA712463 | Binding | Effect on Metabotropic glutamate receptor 7 | 4 | ALA1130227 | single protein format | Scientific Literature | ||
3. | ALA712464 | Functional | Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells | 6 | ALA1148386 | cell-based format | Scientific Literature | ||
4. | ALA712465 | Functional | Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells; Not tested | 5 | ALA1148386 | cell-based format | Scientific Literature | ||
5. | ALA712466 | Functional | Metabotropic glutamate receptor 7 antagonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells | 1 | ALA1148386 | cell-based format | Scientific Literature | ||
6. | ALA1678455 | Binding | Positive allosteric modulation in rat mGluR7 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response at 10 uM | Rattus norvegicus | 1 | ALA1671788 | cell-based format | Scientific Literature | |
7. | ALA1696003 | Binding | Potentiation of rat mGluR7 receptor assessed as fold shift in glutamate concentration response curve at 10 uM relative to control | Rattus norvegicus | 1 | ALA1687701 | single protein format | Scientific Literature | |
8. | ALA839722 | Binding | Binding affinity towards metabotropic glutamate receptor 7 of rat expressed in CHO cells was determined by using [3H]MGS-0008 | Rattus norvegicus | 2 | ALA1138738 | cell-based format | Scientific Literature | |
9. | ALA912664 | Functional | Activity at rat mGluR7 receptor measured as intracellular calcium concentration in HEK293 cells | Rattus norvegicus | 2 | ALA1137262 | cell-based format | Scientific Literature | |
10. | ALA896249 | Functional | Agonist activity at rat mGluR7 receptor expressed HEK293 cells assessed as effect on inositol phosphate production | Rattus norvegicus | 4 | ALA1148786 | cell-based format | Scientific Literature | |
11. | ALA1069931 | Functional | Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR | Rattus norvegicus | 21 | ALA1153226 | cell-based format | Scientific Literature | |
12. | ALA1110796 | Functional | Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader | Rattus norvegicus | 7 | ALA1156339 | cell-based format | Scientific Literature | |
13. | ALA1110797 | Functional | Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting | Rattus norvegicus | 3 | ALA1156339 | cell-based format | Scientific Literature | |
14. | ALA3295731 | Binding | Modulation of rat mGlu7 receptor expressed in HEK293 cells at 10 uM incubated for 2.5 mins prior to glutamate addition measured after 2.5 mins by GIRK assay relative to glutamate | Rattus norvegicus | 7 | ALA3286233 | cell-based format | Scientific Literature | |
15. | ALA3378593 | Binding | Positive allosteric modulator activity at rat mGlu7 receptor expressed in HEK293 cells assessed as L-AP4-induced GIRK channel-mediated thallium flux treated 140s prior to L-AP4 challenge by fluorescence analysis | Rattus norvegicus | 1 | ALA3297742 | cell-based format | Scientific Literature | |
16. | ALA3374994 | Binding | Positive allosteric modulation of rat mGlu7 receptor | Rattus norvegicus | 1 | ALA3351812 | single protein format | Scientific Literature | |
17. | ALA3295863 | Binding | Activity at rat mGlu7 receptor assessed as glutamate-induced GIRK response at 10 uM | Rattus norvegicus | 1 | ALA3286359 | single protein format | Scientific Literature | |
18. | ALA1925098 | Binding | Positive allosteric modulator activity at rat mGlu7 receptor at 10 uM by thallium flux assay relative to glutamate | Rattus norvegicus | 3 | ALA1921795 | single protein format | Scientific Literature | |
19. | ALA1925099 | Functional | Agonist activity at rat mGlu7 receptor at 10 uM by thallium flux assay relative to L-AP4 | Rattus norvegicus | 1 | ALA1921795 | assay format | Scientific Literature | |
20. | ALA1925106 | Functional | Antagonist activity at rat mGlu7 receptor at 10 uM by thallium flux assay | Rattus norvegicus | 3 | ALA1921795 | assay format | Scientific Literature |