# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1017615 | B | Inhibition of human Nav1.1 expressed in HEK293 cells assessed as change in membrane potential using MP-red voltage sensitive dye at 10 uM | Homo sapiens | 5 | ALA1138611 | cell-based format | Scientific Literature | |
2. | ALA2328127 | B | Inhibition of voltage-gated Na channel 1.1 (unknown origin) | Homo sapiens | 2 | ALA2321869 | single protein format | Scientific Literature | |
3. | ALA3242049 | B | Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
4. | ALA3242050 | B | Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
5. | ALA3242051 | B | Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
6. | ALA3242052 | B | Selectivity ratio of IC50 for 10 Hz block of human Nav1.1 to IC50 for blockade of inactivated state of human Nav1.1 by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
7. | ALA3242053 | B | Selectivity ratio of IC50 for tonic block of human Nav1.1 to IC50 for blockade of inactivated state of human Nav1.1 by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
8. | ALA3592065 | B | Inhibition of human Nav1.1 expressed in HEK293 cells assessed as transition of channels to slow-inactivated state at 10 uM measured at -50 mV by whole cell patch-clamp electrophysiology | Homo sapiens | 1 | ALA3588826 | cell-based format | Scientific Literature | |
9. | ALA3592069 | B | Inhibition of human Nav1.1 expressed in HEK293 cells assessed as half-maximal voltage for steady state activation at 10 uM by whole cell patch-clamp electrophysiology (Rvb = -24.69 +/-1.52 mV) | Homo sapiens | 1 | ALA3588826 | cell-based format | Scientific Literature | |
10. | ALA3592073 | B | Inhibition of human Nav1.1 expressed in HEK293 cells assessed as half-maximal voltage for steady state fast-inactivation at 10 uM by whole cell patch-clamp electrophysiology (Rvb = -64.11 +/-3.63 mV) | Homo sapiens | 1 | ALA3588826 | cell-based format | Scientific Literature | |
11. | ALA3592077 | B | Frequency-dependent inhibition of human Nav1.1 expressed in HEK293 cells assessed as current amplitude at 10 uM by whole cell patch-clamp electrophysiology | Homo sapiens | 1 | ALA3588826 | cell-based format | Scientific Literature | |
12. | ALA3590900 | B | Inhibition of human Nav1.1 expressed in HEK293 cells by IonWorks Quattro selectivity assay | Homo sapiens | 2 | ALA3588833 | cell-based format | Scientific Literature | |
13. | ALA3618951 | B | Inhibition of human NaV1.1 channel by patch clamp electrophysiology assay | Homo sapiens | 1 | ALA3616397 | assay format | Scientific Literature | |
14. | ALA3636865 | B | Inhibition of human NaV1.1 by IonWorks quattro automated electrophysiology assay | Homo sapiens | 27 | ALA3632552 | single protein format | Scientific Literature | |
15. | ALA3773491 | B | Inhibition of NaV1.1 (unknown origin) | Homo sapiens | 1 | ALA3769388 | single protein format | Scientific Literature | |
16. | ALA3806744 | B | Inhibition of full length human Nav1.1 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -40 mV by automated voltage clamp analysis | Homo sapiens | 2 | ALA3804797 | cell-based format | Scientific Literature | |
17. | ALA3813332 | B | Inhibition of 10 Hz stimulated Nav1.1 (unknown origin) assessed as inhibition of peak sodium current at 10 uM by automated patch clamp method relative to control | Homo sapiens | 11 | ALA3808373 | assay format | Scientific Literature | |
18. | ALA3813475 | B | Inhibition of 1 Hz stimulated Nav1.1 (unknown origin) by manual patch clamp method | Homo sapiens | 2 | ALA3808373 | assay format | Scientific Literature | |
19. | ALA3813476 | B | Inhibition of 10 Hz stimulated Nav1.1 (unknown origin) by manual patch clamp method | Homo sapiens | 2 | ALA3808373 | assay format | Scientific Literature | |
20. | ALA3810562 | B | Inhibition of human Nav 1.1 assessed as reduction in peak channel current at 1 uM measured at 0.1 Hz by manual patch clamp assay | Homo sapiens | 1 | ALA3808345 | assay format | Scientific Literature |