# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3602693 | Binding | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as thermostability of protein-compound complex at 10 uM after 30 mins by CD spectroscopic analysis | Human immunodeficiency virus 1 | 3 | ALA3600303 | single protein format | Scientific Literature | |
2. | ALA3602694 | Binding | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as 6-helix bundle formation at 100 uM by ITC analysis | Human immunodeficiency virus 1 | 2 | ALA3600303 | single protein format | Scientific Literature | |
3. | ALA3602695 | Binding | Inhibition of HIV-1 HXB2 gp41 N-terminal heptad repeat-mediated fusion between infected HL2/3 cells to target TZM-bl cells after 6 hrs by luciferase reporter gene assay | Human immunodeficiency virus 1 | 11 | ALA3600303 | cell-based format | Scientific Literature | |
4. | ALA3602701 | Binding | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as inhibition of 6-helix bundle formation after 30 mins by ELISA | Human immunodeficiency virus 1 | 2 | ALA3600303 | single protein format | Scientific Literature | |
5. | ALA3602917 | Binding | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as increase in 6-helix bundle thermostability at 10 uM after 30 mins by CD spectroscopic analysis | Human immunodeficiency virus 1 | 1 | ALA3600303 | single protein format | Scientific Literature | |
6. | ALA3602918 | Binding | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as thermostability of compound at 10 uM after 30 mins by CD spectroscopic analysis | Human immunodeficiency virus 1 | 6 | ALA3600303 | single protein format | Scientific Literature | |
7. | ALA3602919 | Binding | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as thermostability of compound after 30 mins by CD spectroscopic analysis | Human immunodeficiency virus 1 | 2 | ALA3600303 | single protein format | Scientific Literature | |
8. | ALA654501 | Binding | Tested for ability to block the CD4-gp120 interaction measured by binding of [125I]sCD4 to gp120 | 1 | ALA1151082 | single protein format | Scientific Literature | ||
9. | ALA655875 | Binding | Tested for inhibition of HIV gp120-CD4 interaction in an ELISA based binding assay using recombinant CD4-gp120 | 1 | ALA1126407 | single protein format | Scientific Literature | ||
10. | ALA655876 | Binding | Tested for inhibition of binding of soluble recombinant CD4-gp120 using ELISA assay | 3 | ALA1151082 | single protein format | Scientific Literature | ||
11. | ALA655877 | Binding | Tested for inhibition of binding of soluble recombinant CD4-gp120 using ELISA assay; IA is Inactive | 10 | ALA1151082 | single protein format | Scientific Literature | ||
12. | ALA655878 | Binding | Tested in an HIV viral syncytium assay for inhibition of binding of recombinant CD4-gp120 | 1 | ALA1151082 | single protein format | Scientific Literature | ||
13. | ALA655879 | Binding | Tested for inhibition of HIV CD4-gp120 interaction in an ELISA based binding assay using recombinant gp120 and soluble CD4 up to a concentration of 350 uM; No inhibition | 2 | ALA1126407 | single protein format | Scientific Literature | ||
14. | ALA655880 | Binding | Tested for inhibition of HIV CD4-gp120 interaction in an ELISA based binding assay using recombinant gp120 and soluble CD4 up to a concentration of 550 uM; No inhibition | 1 | ALA1126407 | single protein format | Scientific Literature | ||
15. | ALA655881 | Binding | Tested for rate constant of binding to inhibit soluble recombinant CD4-gp120; value ranges form 4-20 uM | 1 | ALA1151082 | single protein format | Scientific Literature | ||
16. | ALA692010 | Binding | Binding affinity towards HIV glycoprotein gp120 | 1 | ALA1132866 | single protein format | Scientific Literature | ||
17. | ALA822507 | Functional | In vitro for the cytotoxicity against the gp41 core domain(HIV-I). | 16 | ALA1132348 | assay format | Scientific Literature | ||
18. | ALA1245741 | Binding | Inhibition of HIV1 HXB2 gp120-mediated viral infusion into HEK293 cells after 24 hrs by luciferase reporter gene assay | Human immunodeficiency virus 1 | 1 | ALA1240366 | cell-based format | Scientific Literature | |
19. | ALA1245742 | Binding | Inhibition of HIV1 HXB2 gp120-mediated viral infusion into HEK293 cells after 24 hrs by luciferase reporter gene assay relative to control | Human immunodeficiency virus 1 | 1 | ALA1240366 | cell-based format | Scientific Literature | |
20. | ALA1245745 | Binding | Inhibition of HIV1 HXB2 gp120-mediated viral infusion into HEK293 cells after 24 hrs by luciferase reporter gene assay in presence of 45 mg/ml human serum albumin | Human immunodeficiency virus 1 | 1 | ALA1240366 | cell-based format | Scientific Literature |