| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA749389 | B | Inhibition of the response to NMDA glutamate/glycine receptor NR2A subtype was determined using FLIPR assay | 5 | single protein format | Scientific Literature | |||
| 2. | ALA753012 | F | Antagonistic activity against NR1A/2A receptors in frog oocytes | frog | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA856829 | B | Activity at human NR2A expressed in Ltk- cells by calcium flux assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA907929 | B | Activity at human NR2A expressed in Ltk- cells by patch clamp assay upto 30 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA1781199 | F | Antagonist activity at NR2A transfected in oocytes upto 90 uM | 6 | cell-based format | Scientific Literature | |||
| 6. | ALA1781200 | F | Antagonist activity at NR2A transfected in oocytes | 1 | cell-based format | Scientific Literature | |||
| 7. | ALA4009450 | B | Negative allosteric modulation of eGFP-fused human GluN2A receptor expressed in HEK293T cells assessed as inhibition of NMDA-induced channel current at -60 mV holding potential measured for 5 secs every 60 secs in presence of glycine by whole cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4149878 | B | Negative allosteric modulation of human GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced channel current at 3 uM after 10 to 15 mins by two electrode voltage clamp based electrophysiology assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4308994 | B | Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calcium flux preincubated for 5 mins followed by glycine/glutamate addition by Fluo-4-AM dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4308998 | B | Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel current at -40 mV holding potential by two electrode voltage clamp method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4309002 | B | Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular calcium flux preincubated for 10 mins followed by glycine/glutamate addition and measured for 3 mins by Fluo-8-AM dye based fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4309003 | B | Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced channel current by two electrode voltage clamp method | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 13. | ALA4309005 | B | Positive allosteric modulation of GluN2A receptor (unknown origin) expressed in HEK cell assessed as increase in glycine-induced calcium influx | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4309009 | B | Positive allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channel current by two electrode voltage clamp method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 15. | ALA4309012 | B | Positive allosteric modulation of EGFP-fused human GluN2A receptor expressed in HEK293T cells assessed as increase in glycine-induced channel current by two electrode voltage clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5058656 | B | GluN2A-containing NMDA receptor (Ca2+ influx) assay (EC50) | Homo sapiens | 2 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
| 17. | ALA5058657 | B | GluN2A-containing NMDA receptor (Ca2+ influx) assay (potentiation) | Homo sapiens | 2 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
| 18. | ALA5145398 | B | Positive allosteric modulator activity at GluN2A receptor (unknown origin) by FLIPR assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 19. | ALA5145399 | B | Positive allosteric modulator activity at GluN2A receptor (unknown origin) assessed as maximum potentiation by FLIPR assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 20. | ALA5243882 | B | Positive allosteric modulator activity at GluN2A NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 18 | cell-based format | Scientific Literature |
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