# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3611632 | Binding | Antagonist activity at NK1 receptor in guinea pig ileum assessed as inhibition of substance P-induced muscle contraction in presence of naloxone | Cavia porcellus | 10 | ALA3608260 | tissue-based format | Scientific Literature | |
2. | ALA3738449 | Binding | Agonist activity at neurokinin-1 receptor in Hartley guniea pig isolated ileum/Longitudinal Muscle with Myenteric Plexus assessed as inhibition of electrically-stimulated muscle contraction at 100 nM | Cavia porcellus | 3 | ALA3734657 | tissue-based format | Scientific Literature | |
3. | ALA3738450 | Binding | Agonist activity at neurokinin-1 receptor in Hartley guniea pig isolated ileum/Longitudinal Muscle with Myenteric Plexus assessed as inhibition of electrically-stimulated muscle contraction at 30 nM | Cavia porcellus | 4 | ALA3734657 | tissue-based format | Scientific Literature | |
4. | ALA3738451 | Binding | Agonist activity at neurokinin-1 receptor in Hartley guniea pig isolated ileum/Longitudinal Muscle with Myenteric Plexus assessed as inhibition of electrically-stimulated muscle contraction at 300 nM | Cavia porcellus | 2 | ALA3734657 | tissue-based format | Scientific Literature | |
5. | ALA3738452 | Binding | Antagonist activity at neurokinin-1 receptor in Hartley guniea pig isolated ileum/Longitudinal Muscle with Myenteric Plexus assessed as inhibition of electrically-stimulated muscle contraction | Cavia porcellus | 10 | ALA3734657 | tissue-based format | Scientific Literature | |
6. | ALA3738453 | Binding | Agonist activity at neurokinin-1 receptor in Hartley guniea pig isolated ileum assessed as inhibition of electrically-stimulated muscle contraction at 1 uM | Cavia porcellus | 1 | ALA3734657 | tissue-based format | Scientific Literature | |
7. | ALA680356 | Functional | inhibiting substance P-induced contraction of the isolated guinea pig ileum | Cavia porcellus | 1 | ALA1135382 | tissue-based format | Scientific Literature | |
8. | ALA689225 | Functional | Evaluated in vitro for percent agonist activity in guinea pig ileum (substance P receptor) | Cavia porcellus | 39 | ALA1123529 | tissue-based format | Scientific Literature | |
9. | ALA689633 | Functional | In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane | Cavia porcellus | 1 | ALA1127564 | cell membrane format | Scientific Literature | |
10. | ALA834883 | Functional | Antagonist activity against tachykinin receptor 1 activity in guinea pig ileum in vitro | Cavia porcellus | 17 | ALA1142019 | tissue-based format | Scientific Literature | |
11. | ALA834884 | Functional | Antagonist activity against tachykinin receptor 1 activity in guinea pig ileum in vitro | Cavia porcellus | 4 | ALA1142020 | tissue-based format | Scientific Literature | |
12. | ALA918153 | Functional | Antagonist activity at NK1 receptor in guinea pig ileum assessed as effect on substance P methyl ester-induced mechanical activity | Cavia porcellus | 5 | ALA1149315 | tissue-based format | Scientific Literature | |
13. | ALA905192 | Functional | Agonist activity at NK1 receptor in Hartley guinea pig isolated ileum assessed as muscle contraction relative to KCl | Cavia porcellus | 7 | ALA1143706 | tissue-based format | Scientific Literature | |
14. | ALA905193 | Functional | Antagonist activity at NK1 receptor in Hartley guinea pig isolated ileum assessed as inhibition of substance P-induced muscle contraction | Cavia porcellus | 9 | ALA1143706 | tissue-based format | Scientific Literature | |
15. | ALA906429 | Functional | Antagonist activity at guinea pig NK1 receptor assessed as effect on ileum contractions | Cavia porcellus | 12 | ALA1143716 | tissue-based format | Scientific Literature | |
16. | ALA906307 | Functional | Antagonist activity at NK1 receptor in guinea pig trachea as inhibition of ASM-SP-induced bronchoconstriction relative to control | Cavia porcellus | 2 | ALA1144575 | tissue-based format | Scientific Literature | |
17. | ALA906308 | Functional | Antagonist activity at NK1 receptor in guinea pig trachea as inhibition of ASM-SP-induced bronchoconstriction | Cavia porcellus | 2 | ALA1144575 | tissue-based format | Scientific Literature | |
18. | ALA906306 | Functional | Antagonist activity at NK1 receptor in guinea pig trachea as inhibition of ASM-SP-induced bronchoconstriction up to 1 uM | Cavia porcellus | 5 | ALA1144575 | tissue-based format | Scientific Literature | |
19. | ALA1046463 | Functional | Antagonist activity at NK1 receptor in guinea pig ileum assessed as inhibition of substance P-induced muscle contraction in presence of naloxone | Cavia porcellus | 5 | ALA1152616 | tissue-based format | Scientific Literature | |
20. | ALA1217625 | Functional | Antagonist activity at NK1 receptor in guinea pig ileum assessed as inhibition of substance P-induced muscle contraction | Cavia porcellus | 6 | ALA1212839 | tissue-based format | Scientific Literature |
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