# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3579113 | Binding | Binding affinity to guinea pig OP2 receptor at 1 uM | Cavia porcellus | 4 | ALA3576859 | single protein format | Scientific Literature | |
2. | ALA3584105 | Binding | Displacement of [3H]nor-BNI from kappa opioid receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis | Cavia porcellus | 13 | ALA3580572 | cell membrane format | Scientific Literature | |
3. | ALA3591315 | Binding | Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay | Cavia porcellus | 16 | ALA3588754 | single protein format | Scientific Literature | |
4. | ALA3637630 | Binding | Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting | Cavia porcellus | 12 | ALA3632621 | cell membrane format | Scientific Literature | |
5. | ALA3762646 | Binding | Displacement of [3H]nor-BNI from KOR in Dunkin Hartley guinea pig brain homogenates by liquid scintillation counting analysis | Cavia porcellus | 6 | ALA3758180 | tissue-based format | Scientific Literature | |
6. | ALA3769092 | Binding | Displacement of [3H]nor-BNI from KOR in Dunkin Hartley guinea pig brain homogenate by scintillation counting analysis | Cavia porcellus | 5 | ALA3763121 | tissue-based format | Scientific Literature | |
7. | ALA3766866 | Binding | Displacement of [3H]U69,593 from guinea pig KOR after 2 hrs by liquid scintillation counting method | Cavia porcellus | 11 | ALA3763066 | single protein format | Scientific Literature | |
8. | ALA3790687 | Binding | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig brain membarnes by liquid scintillation counting method | Cavia porcellus | 4 | ALA3785048 | assay format | Scientific Literature | |
9. | ALA3826759 | Binding | Displacement of [3H]U69,593 from kappa-type opioid receptor in guniea pig brain membranes incubated for 2 hrs | Cavia porcellus | 6 | ALA3822449 | cell membrane format | Scientific Literature | |
10. | ALA680352 | Functional | Antagonism activity for the compound was determined by preincubating the muscle preparation with the test compound, ethylketazocine (EK) | Cavia porcellus | 1 | ALA1131025 | tissue-based format | Scientific Literature | |
11. | ALA680353 | Functional | Tested for antagonist potency against kappa receptor using ethylketazocine ligand in guinea pig ileal longitudinal muscle at 100 nM concentration | Cavia porcellus | 1 | ALA1127619 | assay format | Scientific Literature | |
12. | ALA680239 | Functional | Ratio of IC50 of ethylketazocine (agonist) after 10 min of incubation along with compound (antagonist) and IC50 of agonist in absence of compound for kappa opioid receptor at 1 uM in GPI assay | Cavia porcellus | 1 | ALA1123840 | assay format | Scientific Literature | |
13. | ALA680240 | Functional | Ratio of IC50 of ethylketazocine (agonist) after 10 min of incubation along with compound (antagonist) and IC50 of agonist in absence of compound for kappa opioid receptor at 1 uM in GPI assay (Exp 1) | Cavia porcellus | 3 | ALA1123840 | assay format | Scientific Literature | |
14. | ALA680241 | Functional | Ratio of IC50 of ethylketazocine (agonist) after 10 min of incubation along with compound (antagonist) and IC50 of agonist in absence of compound for kappa opioid receptor at 1 uM in GPI assay (Exp 2) | Cavia porcellus | 2 | ALA1123840 | assay format | Scientific Literature | |
15. | ALA687417 | Functional | Percentage inhibition of U-69,593-stimulated [35S]GTP-gamma-S, binding to kappa opioid receptor in guinea pig caudate membranes by 10 uM of compound | Cavia porcellus | 4 | ALA1132914 | cell membrane format | Scientific Literature | |
16. | ALA684852 | Functional | Opioid antagonistic activity was measured against kappa receptor in guinea pig ileal preparation using US-50488 as agonist | Cavia porcellus | 1 | ALA1127466 | assay format | Scientific Literature | |
17. | ALA684853 | Functional | Tested for antagonist potency against kappa receptor using ethylketazocine ligand in guinea pig ileal longitudinal muscle at 100 nM concentration | Cavia porcellus | 5 | ALA1127619 | assay format | Scientific Literature | |
18. | ALA684854 | Functional | Tested for antagonist potency against kappa receptor using ethylketazocine ligand in guinea pig ileal longitudinal muscle at 100 nM concentration; cannot be calculated | Cavia porcellus | 1 | ALA1127619 | assay format | Scientific Literature | |
19. | ALA687456 | Functional | Compound was evaluated for kappa opioid receptor mediated agonistic effect in electrically stimulated guinea-pig ileum | Cavia porcellus | 4 | ALA1153667 | tissue-based format | Scientific Literature | |
20. | ALA688105 | Functional | Antagonist activity against electrically stimulated guinea pig ileum using ethylketazocine (EK) as kappa opioid receptor agonist | Cavia porcellus | 8 | ALA1130045 | tissue-based format | Scientific Literature |