| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA680352 | F | Antagonism activity for the compound was determined by preincubating the muscle preparation with the test compound, ethylketazocine (EK) | Cavia porcellus | 1 | tissue-based format | Scientific Literature | ||
| 2. | ALA680353 | F | Tested for antagonist potency against kappa receptor using ethylketazocine ligand in guinea pig ileal longitudinal muscle at 100 nM concentration | Cavia porcellus | 1 | assay format | Scientific Literature | ||
| 3. | ALA680239 | F | Ratio of IC50 of ethylketazocine (agonist) after 10 min of incubation along with compound (antagonist) and IC50 of agonist in absence of compound for kappa opioid receptor at 1 uM in GPI assay | Cavia porcellus | 1 | assay format | Scientific Literature | ||
| 4. | ALA680240 | F | Ratio of IC50 of ethylketazocine (agonist) after 10 min of incubation along with compound (antagonist) and IC50 of agonist in absence of compound for kappa opioid receptor at 1 uM in GPI assay (Exp 1) | Cavia porcellus | 3 | assay format | Scientific Literature | ||
| 5. | ALA680241 | F | Ratio of IC50 of ethylketazocine (agonist) after 10 min of incubation along with compound (antagonist) and IC50 of agonist in absence of compound for kappa opioid receptor at 1 uM in GPI assay (Exp 2) | Cavia porcellus | 2 | assay format | Scientific Literature | ||
| 6. | ALA687417 | F | Percentage inhibition of U-69,593-stimulated [35S]GTP-gamma-S, binding to kappa opioid receptor in guinea pig caudate membranes by 10 uM of compound | Cavia porcellus | 4 | cell membrane format | Scientific Literature | ||
| 7. | ALA684852 | F | Opioid antagonistic activity was measured against kappa receptor in guinea pig ileal preparation using US-50488 as agonist | Cavia porcellus | 1 | assay format | Scientific Literature | ||
| 8. | ALA684853 | F | Tested for antagonist potency against kappa receptor using ethylketazocine ligand in guinea pig ileal longitudinal muscle at 100 nM concentration | Cavia porcellus | 5 | assay format | Scientific Literature | ||
| 9. | ALA684854 | F | Tested for antagonist potency against kappa receptor using ethylketazocine ligand in guinea pig ileal longitudinal muscle at 100 nM concentration; cannot be calculated | Cavia porcellus | 1 | assay format | Scientific Literature | ||
| 10. | ALA687456 | F | Compound was evaluated for kappa opioid receptor mediated agonistic effect in electrically stimulated guinea-pig ileum | Cavia porcellus | 4 | tissue-based format | Scientific Literature | ||
| 11. | ALA688105 | F | Antagonist activity against electrically stimulated guinea pig ileum using ethylketazocine (EK) as kappa opioid receptor agonist | Cavia porcellus | 8 | tissue-based format | Scientific Literature | ||
| 12. | ALA701392 | F | [35S]GTP-gamma-S, induced maximal stimulation ( E max )against Kappa opioid receptor in guinea pig caudate membranes blocked with 6 nM nor-BNI | Cavia porcellus | 3 | cell membrane format | Scientific Literature | ||
| 13. | ALA701393 | F | [35S]GTP-gamma-S, induced maximal stimulation ( E max )against Kappa opioid receptor in guinea pig caudate membranes blocked with 6 nM nor-BNI | Cavia porcellus | 4 | cell membrane format | Scientific Literature | ||
| 14. | ALA701394 | F | [35S]GTP-gamma-S, induced maximal stimulation ( E max )against Kappa opioid receptor in guinea pig caudate membranes blocked with 6 nM nor-BNI | Cavia porcellus | 1 | cell membrane format | Scientific Literature | ||
| 15. | ALA701395 | F | [35S]GTP-gamma-S, induced maximal stimulation ( E max )against Kappa opioid receptor in guinea pig caudate membranes blocked with 6 nM nor-BNI | Cavia porcellus | 1 | cell membrane format | Scientific Literature | ||
| 16. | ALA701396 | B | Binding to kappa opioid receptor by using [3H]U-69593 as radioligand in guinea pig cerebellum | Cavia porcellus | 11 | tissue-based format | Scientific Literature | ||
| 17. | ALA701397 | B | Compound was tested in vitro for binding affinity towards kappa opioid receptor by measuring displacement of [3H]EKC from guinea pig brain membranes | Cavia porcellus | 3 | assay format | Scientific Literature | ||
| 18. | ALA701398 | F | Binding affinity against kappa opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6 nM nor-BNI | Cavia porcellus | 4 | cell membrane format | Scientific Literature | ||
| 19. | ALA701399 | F | Binding affinity against kappa opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6 nM nor-BNI | Cavia porcellus | 4 | cell membrane format | Scientific Literature | ||
| 20. | ALA701400 | B | Ability to displace [3H]U-69593 from kappa opioid receptor | Cavia porcellus | 5 | single protein format | Scientific Literature |
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