| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA939190 | B | Inhibition of PAR4-mediated GYPGKF-induced ATP release in human platelet assessed per 3*10^8 platelets at 0.2 uM | Homo sapiens | 2 | ALA1143961 | assay format | Scientific Literature | |
| 2. | ALA938345 | B | Inhibition of PAR4-mediated GYPGKF-induced ATP release in human platelet assessed per 3*10^8 platelets at 0.1 uM | Homo sapiens | 2 | ALA1143961 | assay format | Scientific Literature | |
| 3. | ALA938346 | B | Inhibition of PAR4-mediated GYPGKF-induced ATP release in human platelet assessed per 3*10^8 platelets at 1 uM | Homo sapiens | 1 | ALA1143961 | assay format | Scientific Literature | |
| 4. | ALA938347 | B | Inhibition of PAR4-mediated GYPGKF-induced ATP release in human platelet assessed per 3*10^8 platelets at 5 uM | Homo sapiens | 1 | ALA1143961 | assay format | Scientific Literature | |
| 5. | ALA938348 | B | Inhibition of PAR4-mediated GYPGKF-induced P-selectin expression in human platelet at 0.1 uM | Homo sapiens | 2 | ALA1143961 | assay format | Scientific Literature | |
| 6. | ALA938349 | B | Inhibition of PAR4-mediated GYPGKF-induced P-selectin expression in human platelet at 0.05 uM | Homo sapiens | 2 | ALA1143961 | assay format | Scientific Literature | |
| 7. | ALA938350 | B | Inhibition of PAR4-mediated GYPGKF-induced P-selectin expression in human platelet at 1 uM | Homo sapiens | 1 | ALA1143961 | assay format | Scientific Literature | |
| 8. | ALA938351 | B | Inhibition of PAR4-mediated GYPGKF-induced P-selectin expression in human platelet at 5 uM | Homo sapiens | 1 | ALA1143961 | assay format | Scientific Literature | |
| 9. | ALA996097 | F | Agonist activity at PAR4 | 2 | ALA1140059 | assay format | Scientific Literature | ||
| 10. | ALA965449 | B | Activity at PAR4 | 1 | ALA1150318 | single protein format | Scientific Literature | ||
| 11. | ALA1061659 | F | Antagonist activity at PAR4 expressed in Cos7 cells assessed as AYPGKF-mediated SRE-luciferase activity | 2 | ALA1153543 | cell-based format | Scientific Literature | ||
| 12. | ALA3390699 | B | Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets compound pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation assay | Homo sapiens | 11 | ALA3352238 | assay format | Scientific Literature | |
| 13. | ALA3390701 | B | Antagonist activity at PAR4 in PAR-4-AP-stimulated human platelets assessed as PAC1 binding at 10 uM pretreated for 5 mins by fluorescent PAC1 integrin alpha2bb3 activation assay relative to control | Homo sapiens | 33 | ALA3352238 | assay format | Scientific Literature | |
| 14. | ALA3721139 | F | Antagonist activity against human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2-induced intracellular calcium mobilization incubated for 30 mins by FLIPR assay | Homo sapiens | 310 | ALA3714747 | cell-based format | Patent Bioactivity Data | |
| 15. | ALA3721140 | F | Antagonist activity against PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation pre-incubated for 5 mins before gamma-thrombin addition by microplate aggregation assay | Homo sapiens | 68 | ALA3714747 | cell-free format | Patent Bioactivity Data | |
| 16. | ALA3721141 | F | Antagonist activity against PAR4 in washed human platelets assessed as inhibition of alpha-thrombin-induced platelet aggregation pre-incubated for 20 mins before alpha-thrombin addition by optical aggretometry | Homo sapiens | 1 | ALA3714747 | assay format | Patent Bioactivity Data | |
| 17. | ALA3721048 | F | Antagonist activity against PAR4 in washed human platelets assessed as inhibition of alpha-thrombin-induced platelet aggregation at 30 to 300 nM pre-incubated for 20 mins before alpha-thrombin addition and measured over 100 to 500 secs by optical aggregometry | Homo sapiens | 1 | ALA3714767 | assay format | Patent Bioactivity Data | |
| 18. | ALA3721050 | F | Antagonist activity against human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2-induced intracellular calcium mobilization incubated for 30 mins before agonist addition by FLIPR assay | Homo sapiens | 105 | ALA3714767 | cell-based format | Patent Bioactivity Data | |
| 19. | ALA3721051 | F | Antagonist activity against PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation pre-incubated for 5 mins before gamma-thrombin addition by microplate aggregation assay | Homo sapiens | 26 | ALA3714767 | cell-free format | Patent Bioactivity Data | |
| 20. | ALA3734170 | F | Antagonist activity against PAR4 in washed human platelets assessed as inhibition of 2.5 nM alpha-thrombin-induced platelet aggregation pre-incubated for 5 mins before alpha-thrombin addition by optical aggregometry | Homo sapiens | 1 | ALA3727363 | assay format | Patent Bioactivity Data |
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