| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1017613 | Binding | Inhibition of Nav1.6 using 20 Hz train of 20 voltage steps from -90 mV with duration of 3.5 ms at 30 uM by paired pulse protocol | 1 | ALA1138611 | single protein format | Scientific Literature | ||
| 2. | ALA1017621 | Binding | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as change in membrane potential using MP-red voltage sensitive dye at 10 uM | Homo sapiens | 3 | ALA1138611 | cell-based format | Scientific Literature | |
| 3. | ALA971440 | Binding | Use-dependent inhibition of human Nav1.6 expressed in HEK293 cells at 10 uM using double-pulse protocol by patch clamp technique | Homo sapiens | 4 | ALA1138611 | cell-based format | Scientific Literature | |
| 4. | ALA971441 | Binding | Use-dependent inhibition of human Nav1.6 expressed in HEK293 cells at 50 uM using double-pulse protocol by patch clamp technique | Homo sapiens | 4 | ALA1138611 | cell-based format | Scientific Literature | |
| 5. | ALA971448 | Binding | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as change in membrane potential at 10 uM by patch clamp technique | Homo sapiens | 4 | ALA1138611 | cell-based format | Scientific Literature | |
| 6. | ALA971449 | Binding | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as change in membrane potential at 50 uM by patch clamp technique | Homo sapiens | 4 | ALA1138611 | cell-based format | Scientific Literature | |
| 7. | ALA971451 | Binding | Inhibition of human Nav1.6 expressed in HEK293 cells assessed as change in membrane potential using MP-red voltage sensitive dye | Homo sapiens | 2 | ALA1138611 | cell-based format | Scientific Literature | |
| 8. | ALA3383893 | Binding | Effect on human NaV1.6 expressed in HEK293 cells assessed as effect on sodium current by whole cell patch clamp electrophysiology method | Homo sapiens | 1 | ALA3351226 | cell-based format | Scientific Literature | |
| 9. | ALA4386311 | ADME | Inhibition of full length human Nav1.6 expressed in CHO cells at -60 mV holding potential by manual patch clamp electrophysiology method | Homo sapiens | 1 | ALA4385607 | cell-based format | Scientific Literature | |
| 10. | ALA3242074 | Binding | Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
| 11. | ALA3242075 | Binding | Inhibition of human Nav1.6 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
| 12. | ALA3242217 | Binding | Inhibition of human Nav1.6 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
| 13. | ALA3242218 | Binding | Selectivity ratio of IC50 for 10 Hz block of human Nav1.6 to IC50 for blockade of inactivated state of human Nav1.6 by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
| 14. | ALA3242219 | Binding | Selectivity ratio of IC50 for tonic block of human Nav1.6 to IC50 for blockade of inactivated state of human Nav1.6 by patch-clamp electrophysiology/cell based assay | Homo sapiens | 2 | ALA3232919 | cell-based format | Scientific Literature | |
| 15. | ALA2328123 | Binding | Inhibition of voltage-gated Na channel 1.6 (unknown origin) | Homo sapiens | 2 | ALA2321869 | single protein format | Scientific Literature | |
| 16. | ALA2395263 | Binding | Binding affinity to inactivated state of NaV1.6 channel (unknown origin) by whole-cell patch clamp assay | Homo sapiens | 1 | ALA2390921 | assay format | Scientific Literature | |
| 17. | ALA3618955 | Binding | Inhibition of human NaV1.6 channel by patch clamp electrophysiology assay | Homo sapiens | 1 | ALA3616397 | assay format | Scientific Literature | |
| 18. | ALA3800779 | Binding | Inhibition of recombinant human Nav1.6 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay | Homo sapiens | 4 | ALA3797111 | cell-based format | Scientific Literature | |
| 19. | ALA3806747 | Binding | Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by automated voltage clamp analysis | Homo sapiens | 2 | ALA3804797 | cell-based format | Scientific Literature | |
| 20. | ALA3810567 | Binding | Inhibition of human Nav 1.6 assessed as reduction in peak channel current at 1 uM measured at 0.1 Hz by manual patch clamp assay | Homo sapiens | 1 | ALA3808345 | assay format | Scientific Literature |
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