# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA686253 | Functional | Relative potency as ratio of the EC50 value of analogue to that of [PGlu6]SP6-11 in tachykinin receptor 3 in guinea pig ileum | Cavia porcellus | 2 | ALA1125177 | tissue-based format | Scientific Literature | |
2. | ALA1037633 | Functional | Agonist activity at guinea pig NK3 receptor expressed in cells assessed as accumulation of [3H]inositol phosphate | Cavia porcellus | 1 | ALA1154606 | cell-based format | Scientific Literature | |
3. | ALA1037635 | Functional | Antagonist activity at wild type guinea pig NK3 receptor expressed in HEK293 cells assessed as inhibition of [MePhe7]NKB-induced accumulation of [3H]inositol phosphate | Cavia porcellus | 2 | ALA1154606 | cell-based format | Scientific Literature | |
4. | ALA1037636 | Functional | Antagonist activity at wild type guinea pig NK3 receptor A1142.58T mutant expressed in HEK293 cells assessed as inhibition of [MePhe7]NKB-induced accumulation of [3H]inositol phosphate | Cavia porcellus | 5 | ALA1154606 | cell-based format | Scientific Literature | |
5. | ALA1037640 | Binding | Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cells | Cavia porcellus | 5 | ALA1154606 | cell-based format | Scientific Literature | |
6. | ALA1037641 | Binding | Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cells | Cavia porcellus | 5 | ALA1154606 | cell-based format | Scientific Literature | |
7. | ALA1039428 | Binding | Binding affinity to guinea pig NK3 receptor expressed in HEK293 cells assessed as association half maximal binding | Cavia porcellus | 1 | ALA1154606 | cell-based format | Scientific Literature | |
8. | ALA1058405 | Binding | Binding affinity to guinea pig NK3 receptor expressed in HEK293 cells assessed as dissociation half maximal binding | Cavia porcellus | 1 | ALA1154606 | cell-based format | Scientific Literature | |
9. | ALA1058406 | Binding | Apparent binding affinity to guinea pig NK3 receptor expressed in HEK293 cells | Cavia porcellus | 1 | ALA1154606 | cell-based format | Scientific Literature | |
10. | ALA1058407 | Binding | Equilibrium binding affinity to guinea pig NK3 receptor expressed in HEK293 cells | Cavia porcellus | 1 | ALA1154606 | cell-based format | Scientific Literature | |
11. | ALA748091 | Functional | Effective dose was measured on NK3 receptors of guinea pig ileum for maximal contraction in the presence of 10e-7 M substance P methyl ester | Cavia porcellus | 1 | ALA1125177 | tissue-based format | Scientific Literature | |
12. | ALA748092 | Functional | Effective dose was measured on NK3 receptors of guinea pig ileum for maximal contraction in the presence of 10e-7 M substance P methyl ester. | Cavia porcellus | 2 | ALA1125177 | tissue-based format | Scientific Literature | |
13. | ALA748093 | Binding | Evaluated for the binding affinity against NK3 receptor at 1 uM | Cavia porcellus | 1 | ALA1126863 | single protein format | Scientific Literature | |
14. | ALA745028 | Functional | Compound was evaluated for NK-3 receptor antagonistic activity in the guinea pig trachea; Inactive | Cavia porcellus | 1 | ALA1128906 | assay format | Scientific Literature | |
15. | ALA750064 | Binding | Binding affinity for NK3 receptor binding sites in guinea pig cortical membranes by using [125I][MePhe7]-NKB as radioligand | Cavia porcellus | 3 | ALA1127709 | cell membrane format | Scientific Literature | |
16. | ALA882643 | Binding | Inhibitory activity against binding of [125I][MePhe7]-NKB SP to tachykinin NK-3 receptor in guinea pig cortical membranes. | Cavia porcellus | 4 | ALA1129185 | cell membrane format | Scientific Literature | |
17. | ALA872437 | Binding | NK3 IC50 determined using [125I]bolton Hunter labeled eledoisin at NK3 receptors from guinea pig cerebral cortex | Cavia porcellus | 3 | ALA1149947 | tissue-based format | Scientific Literature | |
18. | ALA747335 | Binding | Inhibitory activity against binding of [125I][MePhe7]-NKB SP to tachykinin NK-3 receptor in guinea pig cortical membranes at concentration 10 uM | Cavia porcellus | 2 | ALA1129185 | cell membrane format | Scientific Literature | |
19. | ALA857873 | Binding | The compound was tested for binding affinity against Tachykinin receptor 3 from guinea pig cerebral cortex | Cavia porcellus | 1 | ALA1128556 | tissue-based format | Scientific Literature | |
20. | ALA811320 | Binding | Ability to displace [3H]senktide succinyl-[Asp9MePhe8]-SP (6-13)} from Tachykinin receptor 3 of guinea pig cerebral cortex membrane | Cavia porcellus | 1 | ALA1129332 | tissue-based format | Scientific Literature |