| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA904416 | F | Stabilization of p53 in RPE cells at 1 uM after 24 hrs by Western blotting | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 2. | ALA904417 | F | Stabilization of p53 in RPE cells at 5 to 10 uM after 24 hrs by Western blotting relative to HL198C | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 3. | ALA1810530 | B | Increase in p53 phosphorylation in human NTUB1 cells after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA1805688 | B | Thermal stabilization of p53 tetramerization domain-Arg337His mutant peptide assessed as change in transition temperature at 40 uM by CD spectroscopy | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 5. | ALA1805689 | B | Thermal stabilization of p53 tetramerization domain-Arg337His mutant peptide assessed as change in transition temperature at 10 uM by CD spectroscopy | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 6. | ALA1805690 | B | Enhancement of transcriptional activity of EGFP tagged p53 tetramerization domain-Arg337His mutant peptide in NCI-H1299 cells transfected with p53RE-mCherry(NLS) reporter plasmid assessed as increase in fluorescence signal at 20 uM after 11 hrs by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA1805962 | B | Enhancement of transcriptional activity of wild type p53 in NCI-H1299 cells transfectedp53RE-mCherry(NLS) reporter plasmid assessed as increase in fluorescence signal at 20 uM after 11 hrs by fluorescence assay | 1 | cell-based format | Scientific Literature | |||
| 8. | ALA1805963 | B | Enhancement of transcriptional activity of p53 DNA binding domain Arg273His mutant in NCI-H1299 cells transfected p53RE-mCherry(NLS) reporter plasmid assessed as increase in fluorescence signal at 20 uM after 11 hrs by fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA1805964 | B | Enhancement of transcriptional activity of EGFP tagged p53 tetramerization domain-Arg337His mutant peptide in NCI-H1299 cells transfected with p53RE-mCherry(NLS) reporter plasmid assessed as increase in fluorescence signal at 20 uM after 11 hrs by fluorescence assay relative to untreated control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA1826890 | B | Induction of p53 activation in human MCF7 cells assessed as phosphorylation at Ser15 at 3 times IC50 after 4 to 36 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA939816 | B | Increase in p53-Ser15 phosphorylation in human HeLa cells at 100 uM by Western blotting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA991464 | B | Effect on p53-Ser-15 phosphorylation in ataxia telangiectasia mutated and Rad3 related-deficient human HCT116 cells at 1 nM after 1 hr by Western blotting | 1 | cell-based format | Scientific Literature | |||
| 13. | ALA991465 | B | Effect on p53-Ser-15 phosphorylation in ataxia telangiectasia mutated and Rad3 related-deficient human HCT116 cells at 3 nM after 1 hr by Western blotting | 1 | cell-based format | Scientific Literature | |||
| 14. | ALA1052162 | B | Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase reporter assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 15. | ALA1052166 | B | Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrs | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA1226577 | B | Effect on p53 expressed in HEK293 cells assessed as effect on p53-p53 interaction complexes in presence of camptothecin by EYFP and/or YFP Venus fragment based reporter gene assay | 7 | cell-based format | Scientific Literature | |||
| 17. | ALA1226583 | B | Inhibition of p53 expressed in HEK293 cells assessed as effect on p53-p53 interaction complexes in presence of camptothecin by EYFP and/or YFP Venus fragment based reporter gene assay | 2 | cell-based format | Scientific Literature | |||
| 18. | ALA1226716 | B | Inhibition of p53 phosphorylation at Ser15 in human BJ cells-induced senescence with reterovirus infection expressing TRF2-delta-B-delta-M/EGFP | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA1249424 | B | Binding affinity to p53 assessed as reduction in mitochondrial-bound p53 level at 10 uM | 1 | single protein format | Scientific Literature | |||
| 20. | ALA1249425 | B | Binding affinity to p53 assessed as reduction in mitochondrial-bound p53 level at 25 uM | 1 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!