# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3582625 | Binding | Displacement of [3H]rauwolscine from human recombinant adrenergic alpha2C receptor expressed in MDCK cell membranes by radioligand binding assay | Homo sapiens | 1 | ALA3580564 | cell-based format | Scientific Literature | |
2. | ALA3592654 | Binding | Displacement of [3H]RX821002 from human alpha2C adrenergic receptor expressed in CHO cells at 1 uM by scintillation counting analysis | Homo sapiens | 4 | ALA3588770 | cell-based format | Scientific Literature | |
3. | ALA3592968 | Functional | Agonist activity at human recombinant alpha2C adrenoceptor expressed in CHO cells assessed as intracellular cAMP release at 1 uM by HTRF assay | Homo sapiens | 2 | ALA3588770 | cell-based format | Scientific Literature | |
4. | ALA3592969 | Functional | Antagonist activity at human recombinant alpha2C adrenoceptor expressed in CHO cells assessed as inhibition of epinephrine-induced intracellular cAMP release at 1 uM by HTRF assay | Homo sapiens | 2 | ALA3588770 | cell-based format | Scientific Literature | |
5. | ALA3590965 | Binding | Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis | Homo sapiens | 20 | ALA3588743 | cell-based format | Scientific Literature | |
6. | ALA3591120 | Functional | Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis | Homo sapiens | 17 | ALA3588743 | cell-based format | Scientific Literature | |
7. | ALA3591121 | Functional | Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis relative to UK14304 | Homo sapiens | 17 | ALA3588743 | cell-based format | Scientific Literature | |
8. | ALA3591123 | Functional | Antagonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as inhibition of UK14304-induced cytoplasmic calcium mobilization at 20 uM preincubated for 15 mins by fluorometric analysis relative to control | Homo sapiens | 3 | ALA3588743 | cell-based format | Scientific Literature | |
9. | ALA3603449 | Binding | Agonist activity at human alpha2C-adrenergic receptor | Homo sapiens | 1 | ALA3600378 | single protein format | Scientific Literature | |
10. | ALA3610524 | Binding | Binding affinity to alpha2C adrenoceptor (unknown origin) | Homo sapiens | 1 | ALA3608284 | single protein format | Scientific Literature | |
11. | ALA3635167 | Functional | Agonist activity at adrenergic a2C receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM | Homo sapiens | 1 | ALA3632469 | cell-based format | Scientific Literature | |
12. | ALA3635387 | Functional | Antagonist activity at adrenergic a2C receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM | Homo sapiens | 1 | ALA3632469 | cell-based format | Scientific Literature | |
13. | ALA3636153 | Binding | Displacement of [3H]-Clonidine from recombinant human adrenergic alpha2C receptor after 1.5 hrs by Microbeta scintillation counting analysis | Homo sapiens | 1 | ALA3632459 | single protein format | Scientific Literature | |
14. | ALA3736689 | Binding | Displacement of [3H]Rauwolscine from human recombinant alpha 2C receptor stably expressed in MDCK cells after 90 mins by scintillation counting method | Homo sapiens | 1 | ALA3734659 | cell-based format | Scientific Literature | |
15. | ALA3738630 | Binding | Binding affinity to alpha2C adrenergic receptor (unknown origin) | Homo sapiens | 1 | ALA3734753 | single protein format | Scientific Literature | |
16. | ALA3738641 | Functional | Antagonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assay | Homo sapiens | 3 | ALA3734721 | cell-based format | Scientific Literature | |
17. | ALA3738800 | Functional | Agonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | Homo sapiens | 3 | ALA3734721 | cell-based format | Scientific Literature | |
18. | ALA3756489 | Binding | Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay | Homo sapiens | 6 | ALA3751848 | single protein format | Scientific Literature | |
19. | ALA3774022 | Binding | Binding affinity to human alpha-2C adrenergic receptor by radioligand binding assay | Homo sapiens | 1 | ALA3769385 | single protein format | Scientific Literature | |
20. | ALA3774185 | Binding | Binding affinity to human alpha-2C adrenergic receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3769385 | single protein format | Scientific Literature |