# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3425057 | Binding | Displacement of [3H]mesulergine from recombinant human 5HT2B receptor expressed in CHO cells at 1 uM after 60 mins by scintillation counting analysis relative to control | Homo sapiens | 1 | ALA3421625 | cell-based format | Scientific Literature | |
2. | ALA3429515 | Functional | Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay | Homo sapiens | 8 | ALA3425406 | cell-based format | Scientific Literature | |
3. | ALA3429516 | Functional | Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization at 30 uM after 1 hr by FLIPR assay relative to 5-HT | Homo sapiens | 8 | ALA3425406 | cell-based format | Scientific Literature | |
4. | ALA3429517 | Binding | Inhibition of Cy3B conjugated serotonin analogue binding to human recombinant 5-HT2B receptor expressed in CHOK1 cells after 60 mins by fluorescence polarization assay | Homo sapiens | 1 | ALA3425406 | cell-based format | Scientific Literature | |
5. | ALA3583844 | Binding | Binding affinity to 5HT-2B receptor (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3580567 | single protein format | Scientific Literature | |
6. | ALA3584691 | Binding | Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay | Homo sapiens | 1 | ALA3580564 | cell-based format | Scientific Literature | |
7. | ALA3596073 | Binding | Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes at 10 uM | Homo sapiens | 15 | ALA3593163 | cell-based format | Scientific Literature | |
8. | ALA3594621 | Binding | Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes | Homo sapiens | 7 | ALA3593163 | cell-based format | Scientific Literature | |
9. | ALA3594622 | Binding | Potency index, ratio of pKi for 5-HPEC to pKi for test compound against human 5HT2B receptor expressed in stable HEK cells membranes | Homo sapiens | 1 | ALA3593163 | cell-based format | Scientific Literature | |
10. | ALA3594623 | Functional | Agonist activity at human 5HT2B receptor expressed in Flp-IN HEK cells at 10 um by calcium mobilization assay relative to 5-HT | Homo sapiens | 1 | ALA3593163 | cell-based format | Scientific Literature | |
11. | ALA3594624 | Functional | Antagonist activity against human 5HT2B receptor expressed in Flp-IN HEK cells assessed as inhibition of 5-HT-induced response at 10 uM by calcium mobilization assay | Homo sapiens | 2 | ALA3593163 | cell-based format | Scientific Literature | |
12. | ALA3603031 | Binding | Inhibition of 5HT2B receptor (unknown origin) | Homo sapiens | 1 | ALA3600381 | single protein format | Scientific Literature | |
13. | ALA3602040 | Binding | Inhibition of human 5-HT2B receptor at 10 uM relative to control | Homo sapiens | 1 | ALA3600314 | single protein format | Scientific Literature | |
14. | ALA3610061 | Binding | Displacement of [3H]LSD from 5HT2B receptor (unknown origin) at 10 uM | Homo sapiens | 11 | ALA3608284 | single protein format | Scientific Literature | |
15. | ALA3610528 | Binding | Displacement of [3H]LSD from 5HT2B receptor (unknown origin) | Homo sapiens | 12 | ALA3608284 | single protein format | Scientific Literature | |
16. | ALA3616302 | Binding | Binding affinity to 5HT2B receptor (unknown origin) | Homo sapiens | 2 | ALA3612017 | single protein format | Scientific Literature | |
17. | ALA3619184 | Binding | Binding affinity to 5HT2B receptor (unknown origin) at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3616441 | single protein format | Scientific Literature | |
18. | ALA3619185 | Binding | Agonist activity at 5HT2B receptor (unknown origin) up to 10 uM | Homo sapiens | 1 | ALA3616441 | single protein format | Scientific Literature | |
19. | ALA3619186 | Binding | Antagonist activity at 5HT2B receptor (unknown origin) up to 10 uM | Homo sapiens | 1 | ALA3616441 | single protein format | Scientific Literature | |
20. | ALA3624133 | Binding | Inhibition of human 5HT-2B receptor at 10 uM relative to control | Homo sapiens | 2 | ALA3621160 | single protein format | Scientific Literature |