# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3429522 | Binding | Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assay | Homo sapiens | 5 | ALA3425461 | cell-based format | Scientific Literature | |
2. | ALA3429523 | Binding | Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assay relative to 1 uM bexarotene | Homo sapiens | 4 | ALA3425461 | cell-based format | Scientific Literature | |
3. | ALA3429524 | Binding | Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assay relative to untrated control | Homo sapiens | 1 | ALA3425461 | cell-based format | Scientific Literature | |
4. | ALA3599042 | Binding | Antagonist activity at Gal4 DNA binding domain-tagged human RXRalpha ligand binding domain expressed in HEK293 cells assessed as inhibition of receptor-mediated transcriptional activity by luciferase reporter gene assay | Homo sapiens | 1 | ALA3596154 | cell-based format | Scientific Literature | |
5. | ALA3599164 | Binding | Agonist activity at Gal4 DNA binding domain-tagged human RXRalpha ligand binding domain expressed in HEK293 cells assessed as activation of receptor-mediated transcriptional activity by luciferase reporter gene assay | Homo sapiens | 1 | ALA3596154 | cell-based format | Scientific Literature | |
6. | ALA3626678 | Binding | Binding affinity to human RXRalpha LBD by fluorescence quenching method | Homo sapiens | 7 | ALA3621048 | single protein format | Scientific Literature | |
7. | ALA3626679 | Binding | Agonist activity at human RXRalpha LBD expressed in HEK293 cells transfected with Gal4 reporter assessed as increase of transcription by dual luciferase reporter assay | Homo sapiens | 7 | ALA3621048 | cell-based format | Scientific Literature | |
8. | ALA3626681 | Binding | Binding affinity to human RXRalpha LBD at 1:1 protein and compound ratio by fluorescence quenching method relative to control | Homo sapiens | 5 | ALA3621048 | single protein format | Scientific Literature | |
9. | ALA3626682 | Binding | Agonist activity at RXRalpha LBD (unknown origin) expressed in CV1 cells | Homo sapiens | 1 | ALA3621048 | cell-based format | Scientific Literature | |
10. | ALA3626683 | Binding | Agonist activity at human RXRalpha LBD expressed in HEK293 cells transfected with Gal4 reporter assessed as increase of transcription at 1000 nM by dual luciferase reporter assay | Homo sapiens | 1 | ALA3621048 | cell-based format | Scientific Literature | |
11. | ALA3626725 | Binding | Partial agonist activity at human RXRalpha LBD expressed in HEK293 cells transfected with Gal4 reporter assessed as increase of transcription at 1000 nM by dual luciferase reporter assay | Homo sapiens | 1 | ALA3621048 | cell-based format | Scientific Literature | |
12. | ALA3626726 | Binding | Agonist activity at human RXRalpha LBD expressed in HEK293 cells transfected with Gal4 reporter assessed as increase of transcription at 10'-6 M by dual luciferase reporter assay relative to control | Homo sapiens | 10 | ALA3621048 | cell-based format | Scientific Literature | |
13. | ALA3626729 | Binding | Binding affinity to human RXRalpha LBD after 15 mins by isothermal titration calorimetry assay | Homo sapiens | 5 | ALA3621048 | single protein format | Scientific Literature | |
14. | ALA3720928 | Binding | Displacement of [3H]9-cis-retinoic acid from RXRalpha (unknown origin) by radioligand binding assay | Homo sapiens | 20 | ALA3714714 | single protein format | Patent Bioactivity Data | |
15. | ALA3750343 | Binding | Agonist activity at RXRalpha (unknown origin) | Homo sapiens | 1 | ALA3745639 | single protein format | Scientific Literature | |
16. | ALA3776842 | Binding | Inhibition of human RXRalpha | Homo sapiens | 1 | ALA3774309 | single protein format | Scientific Literature | |
17. | ALA3784067 | Binding | Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene assay | Homo sapiens | 11 | ALA3779771 | assay format | Scientific Literature | |
18. | ALA3784068 | Binding | Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene assay relative to bexarotene | Homo sapiens | 7 | ALA3779771 | assay format | Scientific Literature | |
19. | ALA3784071 | Binding | Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay | Homo sapiens | 3 | ALA3779771 | cell-based format | Scientific Literature | |
20. | ALA3784072 | Binding | Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay relative to bexarotene | Homo sapiens | 4 | ALA3779771 | cell-based format | Scientific Literature |