| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1070346 | B | Binding affinity to DNMT3a in human PC3 cells cytoplasm at 5 uM after 6 hrs by antibody staining | Homo sapiens | 1 | ALA1157638 | cell-based format | Scientific Literature | |
| 2. | ALA1819962 | B | Inhibition of human GST-tagged recombinant DNMT3A using [3H]-adenosyl-L-methionine at 50 uM after 2 hrs by scintillation counting | Homo sapiens | 8 | ALA1817548 | single protein format | Scientific Literature | |
| 3. | ALA2209118 | B | Inhibition of DNMT3a using lambda DNA as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 mins | 3 | ALA2202955 | single protein format | Scientific Literature | ||
| 4. | ALA3134969 | B | Inhibition of human DNMT3A catalytic domain (623 to 912 amino acids) after 1 hr by fluorescence assay | Homo sapiens | 1 | ALA3132825 | single protein format | Scientific Literature | |
| 5. | ALA3134970 | B | Inhibition of human DNMT3A catalytic domain (623 to 912 amino acids) at 10 uM after 1 hr by fluorescence assay | Homo sapiens | 8 | ALA3132825 | single protein format | Scientific Literature | |
| 6. | ALA3134971 | B | Inhibition of human DNMT3A catalytic domain (623 to 912 amino acids) at 100 uM after 1 hr by fluorescence assay | Homo sapiens | 8 | ALA3132825 | single protein format | Scientific Literature | |
| 7. | ALA3389594 | B | Inhibition of DNMT3A (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting based radioactive methylation assay | Homo sapiens | 1 | ALA3351464 | single protein format | Scientific Literature | |
| 8. | ALA3418013 | B | Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintillation counting method | Homo sapiens | 4 | ALA3414469 | cell-based format | Scientific Literature | |
| 9. | ALA3578933 | B | Inhibition of human full length DNMT3A expressed in Sf9 cells | Homo sapiens | 2 | ALA3576805 | cell-based format | Scientific Literature | |
| 10. | ALA3607245 | B | Inhibition of human C-terminal DNMT3A after 1 hr by fluorescence assay | Homo sapiens | 4 | ALA3603802 | single protein format | Scientific Literature | |
| 11. | ALA3607246 | B | Inhibition of human C-terminal DNMT3A at 20 uM after 1 hr by fluorescence assay | Homo sapiens | 35 | ALA3603802 | single protein format | Scientific Literature | |
| 12. | ALA3607247 | B | Inhibition of human C-terminal DNMT3A at 32 uM after 1 hr by fluorescence assay | Homo sapiens | 35 | ALA3603802 | single protein format | Scientific Literature | |
| 13. | ALA3871971 | B | Inhibition of N-terminal His6-tagged DNMT3A (623 to 908 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) coexpressing DNMT3L (160 to 386 C-terminal residues) (unknown origin) assessed as reduction in oligonucleosome methylation at 100 uM preincubated for 15 mins followed by addition of [3H]-SAM measured after 4 hrs by liquid scintillation counting method | Homo sapiens | 16 | ALA3871293 | assay format | Scientific Literature | |
| 14. | ALA3871972 | B | Inhibition of N-terminal His6-tagged DNMT3A (623 to 908 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) coexpressing DNMT3L (160 to 386 C-terminal residues) (unknown origin) assessed as reduction in oligonucleosome methylation preincubated for 15 mins followed by addition of [3H]-SAM measured after 4 hrs by liquid scintillation counting method | Homo sapiens | 16 | ALA3871293 | assay format | Scientific Literature | |
| 15. | ALA4015670 | B | Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site after 1 hr by fluorescence assay | Homo sapiens | 11 | ALA4014314 | single protein format | Scientific Literature | |
| 16. | ALA4015671 | B | Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site at 32 uM after 1 hr by fluorescence assay relative to control | Homo sapiens | 50 | ALA4014314 | single protein format | Scientific Literature | |
| 17. | ALA4015672 | B | Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site at 10 uM after 1 hr by fluorescence assay relative to control | Homo sapiens | 50 | ALA4014314 | single protein format | Scientific Literature | |
| 18. | ALA4137486 | B | Inhibition of recombinant human N-terminal GST-tagged DNMT3A (1 to 913 residues) expressed in baculovirus infected Sf9 cells at 10 uM relative to control | Homo sapiens | 2 | ALA4130634 | cell-based format | Scientific Literature | |
| 19. | ALA4195567 | B | Inhibition of full length recombinant human N-terminal GST-tagged DNMT3A (1 to 913 residues) expressed in baculovirus infected Sf9 cells at 10 uM relative to control | Homo sapiens | 3 | ALA4190398 | cell-based format | Scientific Literature | |
| 20. | ALA4315170 | B | Inhibition of human DNMT3a using lambda DNA as substrate incubated for 1 hr in presence of [3H]-SAM by filter binding method | Homo sapiens | 1 | ALA4311997 | single protein format | Scientific Literature |
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