| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA970539 | B | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human recombinant NPC1L1 expressed in HEK293 cells | Homo sapiens | 10 | ALA1136903 | cell-based format | Scientific Literature | |
| 2. | ALA970540 | B | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in human enterocyte brush border membrane | Homo sapiens | 4 | ALA1136903 | assay format | Scientific Literature | |
| 3. | ALA1046285 | B | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human intestinal brush border membrane NPC1L1 by single tube filtration assay | Homo sapiens | 2 | ALA1155303 | assay format | Scientific Literature | |
| 4. | ALA1046286 | B | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from recombinant human NPC1L1 expressed in HEK cells by single tube filtration assay | Homo sapiens | 2 | ALA1155303 | cell-based format | Scientific Literature | |
| 5. | ALA1638621 | B | Binding affinity to human NPC1L1 | Homo sapiens | 1 | ALA1629418 | single protein format | Scientific Literature | |
| 6. | ALA1638622 | B | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human NCP1L1 expressed in HEK 293 | Homo sapiens | 111 | ALA1629418 | cell-based format | Scientific Literature | |
| 7. | ALA3362444 | B | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization at 10 uM after 24 hrs by fluorescence microscopy | Homo sapiens | 14 | ALA3352343 | cell-based format | Scientific Literature | |
| 8. | ALA3362445 | B | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy | Homo sapiens | 33 | ALA3352343 | cell-based format | Scientific Literature | |
| 9. | ALA3362366 | B | Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to plasma membrane at 30 uM after 24 hrs by fluorescence microscopic analysis | Homo sapiens | 54 | ALA3297646 | cell-based format | Scientific Literature | |
| 10. | ALA3362368 | B | Binding affinity to human EGFP-tagged NTD-deleted NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to plasma membrane after 24 hrs by fluorescence microscopic analysis | Homo sapiens | 1 | ALA3297646 | cell-based format | Scientific Literature | |
| 11. | ALA3362369 | B | Binding affinity to human EGFP-tagged full-length NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as protein stabilization after 24 hrs by fluorescence assay | Homo sapiens | 3 | ALA3297646 | cell-based format | Scientific Literature | |
| 12. | ALA3362370 | B | Binding affinity to human EGFP-tagged NTD-deleted NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as protein stabilization after 24 hrs by fluorescence assay | Homo sapiens | 3 | ALA3297646 | cell-based format | Scientific Literature | |
| 13. | ALA3362371 | B | Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to plasma membrane at 10 uM after 24 hrs by fluorescence microscopic analysis | Homo sapiens | 57 | ALA3297646 | cell-based format | Scientific Literature | |
| 14. | ALA3405554 | B | Inhibition of human NPC1L1 transfected in MDCK2 cells assessed as [3H]cholesterol uptake after 1 hr by liquid scintillation counting analysis | Homo sapiens | 6 | ALA3400023 | cell-based format | Scientific Literature | |
| 15. | ALA3405555 | B | Inhibition of human NPC1L1 transfected in MDCK2 cells assessed as [3H]cholesterol uptake at 60 uM after 1 hr by liquid scintillation counting analysis | Homo sapiens | 7 | ALA3400023 | cell-based format | Scientific Literature | |
| 16. | ALA3762456 | B | Inhibition of niemann pick C1-like protein-1 in human Caco-2 cells assessed as cholesterol uptake at 100 uM after 24 hrs by HPLC analysis | Homo sapiens | 9 | ALA3758158 | cell-based format | Scientific Literature | |
| 17. | ALA4221551 | B | Inhibition of NPC1L1 in human Caco2 cells assessed as decrease in cholesterol uptake at 100 uM preincubated for 24 hrs followed by stigmosterol substrate addition measured after 24 hrs by HPLC method relative to control | Homo sapiens | 4 | ALA4219107 | cell-based format | Scientific Literature | |
| 18. | ALA4221559 | B | Inhibition of NPC1L1 in human Caco2 cells assessed as decrease in cholesterol uptake at 100 uM preincubated for 24 hrs followed by stigmosterol substrate addition measured after 24 hrs by HPLC method | Homo sapiens | 10 | ALA4219107 | cell-based format | Scientific Literature | |
| 19. | ALA4816994 | B | Binding affinity to NPC1L1 (unknown origin) at 6.25 to 100 uM by SPR analysis | Homo sapiens | 3 | ALA4813990 | single protein format | Scientific Literature | |
| 20. | ALA4816997 | B | Inhibition of NPC1L1 in human Caco-2 cells assessed as decrease in uptake of cholesterol-d6 at 50 uM by HPLC-MS analysis | Homo sapiens | 3 | ALA4813990 | cell-based format | Scientific Literature |
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