# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3428930 | Functional | Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting | Homo sapiens | 26 | ALA3425497 | cell-based format | Scientific Literature | |
2. | ALA3582626 | Binding | Displacement of [3H]CGP12177 from human recombinant adrenergic beta2 receptor expressed in CHO Flp-In cell membranes by radioligand binding assay | Homo sapiens | 1 | ALA3580564 | cell-based format | Scientific Literature | |
3. | ALA3602032 | Binding | Inhibition of human adrenergic beta2 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA3600314 | single protein format | Scientific Literature | |
4. | ALA3603438 | Functional | Agonist activity at human beta2-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins | Homo sapiens | 4 | ALA3600378 | cell-based format | Scientific Literature | |
5. | ALA3603439 | Functional | Intrinsic activity at human beta2-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins relative to isoproterenol | Homo sapiens | 1 | ALA3600378 | cell-based format | Scientific Literature | |
6. | ALA3610147 | Binding | Binding affinity to beta2 adrenoceptor (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3608284 | single protein format | Scientific Literature | |
7. | ALA3616054 | Binding | Binding affinity to human beta2 adrenergic receptor assessed as inhibition of control specific binding at 10 uM | Homo sapiens | 1 | ALA3612012 | single protein format | Scientific Literature | |
8. | ALA3630579 | Functional | Agonist activity at human beta2 adrenoceptor expressed in CHO cells assessed as stumulation of intracellular cAMP production | Homo sapiens | 7 | ALA3627605 | cell-based format | Scientific Literature | |
9. | ALA3630580 | Binding | Ratio of EC50 for human beta2 adrenoceptor with wash treatment to EC50 for human beta2 adrenoceptor without wash treatment | Homo sapiens | 7 | ALA3627605 | single protein format | Scientific Literature | |
10. | ALA3635169 | Functional | Agonist activity at adrenergic beta2 receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM | Homo sapiens | 1 | ALA3632469 | cell-based format | Scientific Literature | |
11. | ALA3635389 | Functional | Antagonist activity at adrenergic beta2 receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM | Homo sapiens | 1 | ALA3632469 | cell-based format | Scientific Literature | |
12. | ALA3636014 | Binding | Displacement of [3H]-Iodopindolol from recombinant human adrenergic beta2 receptor at 10 uM after 1.5 hrs by Microbeta scintillation counting analysis relative to control | Homo sapiens | 1 | ALA3632459 | single protein format | Scientific Literature | |
13. | ALA3705663 | Binding | Inhibition Assay: Human recombinant adrenergic β2 receptors expressed in CHO cells are used in modified Tris-HCl buffer pH 7.4. A 50 aliquot is incubated with 0.2 nM [3H]CGP-12177 for 60 minutes at 25° C. Non-specific binding is estimated in the presence of 10 μM ICI-118551. Receptors are filtered and washed, the filters are then counted to determine [3H]CGP-12177 specifically bound. Compounds are screened at 10 μM. | Homo sapiens | 1 | ALA3639212 | cell-based format | BindingDB Database | |
14. | ALA3737430 | Binding | Displacement of [3H]CGP12177 from human recombinant beta 2 receptor expressed in HEK Flp-In cells after 90 mins by scintillation counting method | Homo sapiens | 1 | ALA3734659 | cell-based format | Scientific Literature | |
15. | ALA3738004 | Functional | Antagonist activity at human beta2 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay | Homo sapiens | 3 | ALA3734721 | cell-based format | Scientific Literature | |
16. | ALA3744779 | Binding | Inhibition of human beta2-adrenoceptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
17. | ALA3742631 | Binding | Displacement of [3H]-dihydroalprenolol from human beta2 adrenergic receptor expressed in HEK293T cells after 1 to 1.5 hrs by liquid scintillation counting analysis | Homo sapiens | 6 | ALA3739384 | cell-based format | Scientific Literature | |
18. | ALA3750559 | Binding | Displacement of [125I]CYP from human beta-2 adrenergic receptor expressed in CHO cell membrane after 1 hr by scintillation counting method | Homo sapiens | 10 | ALA3745665 | cell-based format | Scientific Literature | |
19. | ALA3754970 | Binding | Inhibition of human beta-2 adrenergic receptor at 10 uM | Homo sapiens | 1 | ALA3751833 | single protein format | Scientific Literature | |
20. | ALA3766831 | Binding | Inhibition of Adrenergic beta2 receptor (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3763120 | single protein format | Scientific Literature |