# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3578598 | Binding | Binding affinity to human adrenergic beta1 receptor at 1 uM | Homo sapiens | 4 | ALA3576859 | single protein format | Scientific Literature | |
2. | ALA3591363 | Binding | Antagonist activity against beta-1 adrenergic receptor (unknown origin) | Homo sapiens | 2 | ALA3588773 | single protein format | Scientific Literature | |
3. | ALA3602031 | Binding | Inhibition of human adrenergic beta1 receptor at 10 uM relative to control | Homo sapiens | 1 | ALA3600314 | single protein format | Scientific Literature | |
4. | ALA3603436 | Functional | Agonist activity at human beta1-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins | Homo sapiens | 4 | ALA3600378 | cell-based format | Scientific Literature | |
5. | ALA3603437 | Functional | Intrinsic activity at human beta1-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins relative to isoproterenol | Homo sapiens | 1 | ALA3600378 | cell-based format | Scientific Literature | |
6. | ALA3610146 | Binding | Binding affinity to beta1 adrenoceptor (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3608284 | single protein format | Scientific Literature | |
7. | ALA3616053 | Binding | Binding affinity to human beta1 adrenergic receptor assessed as inhibition of control specific binding at 10 uM | Homo sapiens | 1 | ALA3612012 | single protein format | Scientific Literature | |
8. | ALA3635168 | Functional | Agonist activity at adrenergic beta1 receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM | Homo sapiens | 1 | ALA3632469 | cell-based format | Scientific Literature | |
9. | ALA3635388 | Functional | Antagonist activity at adrenergic beta1 receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM | Homo sapiens | 1 | ALA3632469 | cell-based format | Scientific Literature | |
10. | ALA3636013 | Binding | Displacement of [3H]-Iodopindolol from recombinant human adrenergic beta1 receptor at 10 uM after 1.5 hrs by Microbeta scintillation counting analysis relative to control | Homo sapiens | 1 | ALA3632459 | single protein format | Scientific Literature | |
11. | ALA3706172 | Binding | Inhibition Assay: Human recombinant adrenergic β1 receptors expressed in CHO-K1 cells are used in modified Tris-HCl buffer pH 7.4. A 25 aliquot is incubated with 0.03 nM [125I]Cyanopindolol for 120 minutes at 25° C. Non-specific binding is estimated in the presence of 100 μM S(−)-Propranolol. Receptors are filtered and washed, the filters are then counted to determine [125I]Cyanopindolol specifically bound. Compounds are screened at 10 μM. | Homo sapiens | 1 | ALA3639212 | cell-based format | BindingDB Database | |
12. | ALA3736688 | Binding | Displacement of [3H]CGP12177 human recombinant beta 1 adrenergic recptor expressed in CHO Flp-In cells after 90 mins by scintillation counting method | Homo sapiens | 1 | ALA3734659 | cell-based format | Scientific Literature | |
13. | ALA3738005 | Functional | Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay | Homo sapiens | 3 | ALA3734721 | cell-based format | Scientific Literature | |
14. | ALA3744778 | Binding | Inhibition of human beta1-adrenoceptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
15. | ALA3744670 | Binding | Binding affinity to beta-1 adrenergic receptor (unknown origin) at 1 uM | Homo sapiens | 2 | ALA3739404 | single protein format | Scientific Literature | |
16. | ALA3750558 | Binding | Displacement of [125I]CYP from human beta-1 adrenergic receptor expressed in CHO cell membrane after 1 hr by scintillation counting method | Homo sapiens | 10 | ALA3745665 | cell-based format | Scientific Literature | |
17. | ALA3754969 | Binding | Inhibition of human beta-1 adrenergic receptor at 10 uM | Homo sapiens | 1 | ALA3751833 | single protein format | Scientific Literature | |
18. | ALA3762991 | Binding | Binding affinity to adrenergic beta1 receptor (unknown origin) at 1 to 2 uM by radioligand binding assay | Homo sapiens | 1 | ALA3758150 | single protein format | Scientific Literature | |
19. | ALA3766832 | Binding | Inhibition of Adrenergic beta1 receptor (unknown origin) at 10 uM | Homo sapiens | 1 | ALA3763120 | single protein format | Scientific Literature | |
20. | ALA3767774 | Binding | Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting method | Homo sapiens | 13 | ALA3763146 | single protein format | Scientific Literature |