# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3736777 | Functional | Antiparasitic activity against Toxoplasma gondii RH tachyzoite expressing beta-galactosidase assessed as inhibition of tachyzoite invasion into human foreskin fibroblast host cells after 96 hrs by colorimetric microtitre assay | Toxoplasma gondii | 22 | ALA3734718 | organism-based format | Scientific Literature | |
2. | ALA3773071 | Functional | Antiprotozoan activity against Toxoplasma gondii infected in fibroblasts assessed as growth inhibition after 44 hrs by beta-galactosidase reporter assay | Toxoplasma gondii | 22 | ALA3769379 | organism-based format | Scientific Literature | |
3. | ALA3773079 | Functional | Antiprotozoan activity against Toxoplasma gondii RH infected in CF-1 mouse assessed as reduction of parasite burden in peritoneal fluid at 50 mg/kg, po qd administered for 5 days measured 24 hrs post last dose by hemocytometer-based fluorescence microscopy | Toxoplasma gondii | 1 | ALA3769379 | organism-based format | Scientific Literature | |
4. | ALA3773080 | Functional | Antiprotozoan activity against Toxoplasma gondii RH infected in CF-1 mouse assessed as reduction of parasite burden in peritoneal fluid at 20 mg/kg, po qd administered for 5 days measured 24 hrs post last dose by hemocytometer-based fluorescence microscopy | Toxoplasma gondii | 2 | ALA3769379 | organism-based format | Scientific Literature | |
5. | ALA3773081 | Functional | Antiprotozoan activity against Toxoplasma gondii RH infected in CF-1 mouse assessed as reduction of parasite burden in peritoneal fluid at 5 to 10 mg/kg, po bid administered for 5 days measured 24 hrs post last dose by hemocytometer-based fluorescence microscopy | Toxoplasma gondii | 1 | ALA3769379 | organism-based format | Scientific Literature | |
6. | ALA3773082 | Functional | Antiprotozoan activity against Toxoplasma gondii RH infected in CF-1 mouse assessed as parasite level in spleen at 20 mg/kg, po qd administered for 5 days measured 24 hrs post last dose by quantitative RT-PCR analysis | Toxoplasma gondii | 1 | ALA3769379 | organism-based format | Scientific Literature | |
7. | ALA3773083 | Functional | Antiprotozoan activity against Toxoplasma gondii RH infected in CF-1 mouse assessed as parasite level in spleen at 20 to 50 mg/kg, po qd administered for 5 days measured 24 hrs post last dose by quantitative RT-PCR analysis relative to control | Toxoplasma gondii | 2 | ALA3769379 | organism-based format | Scientific Literature | |
8. | ALA3773426 | Functional | Antiprotozoan activity against Toxoplasma gondii RH infected in CF-1 mouse assessed as reduction of parasite burden in brain at 20 to 50 mg/kg, po qd administered for 5 days measured 24 hrs post last dose by quantitative RT-PCR analysis relative to control | Toxoplasma gondii | 2 | ALA3769379 | organism-based format | Scientific Literature | |
9. | ALA3773433 | Functional | Antiprotozoan activity against Toxoplasma gondii infected in fibroblasts assessed as growth inhibition at low concentration after 2 days by beta-galactosidase reporter assay | Toxoplasma gondii | 2 | ALA3769379 | organism-based format | Scientific Literature | |
10. | ALA3773434 | Functional | Antiprotozoan activity against Toxoplasma gondii overexpressing wild type CDPK1 infected in fibroblasts assessed as growth inhibition at low concentration after 2 days by beta-galactosidase reporter assay | Toxoplasma gondii | 2 | ALA3769379 | organism-based format | Scientific Literature | |
11. | ALA3773435 | Functional | Antiprotozoan activity against Toxoplasma gondii overexpressing CDPK1 G128M mutant infected in fibroblasts assessed as growth inhibition at low concentration after 2 days by beta-galactosidase reporter assay | Toxoplasma gondii | 2 | ALA3769379 | organism-based format | Scientific Literature | |
12. | ALA3773436 | Functional | Antiprotozoan activity against Toxoplasma gondii RH infected in CF-1 mouse assessed as reduction of parasite burden in peritoneal fluid at 20 to 40 mg/kg, po bid administered for 5 days measured 24 hrs post last dose by hemocytometer-based fluorescence microscopy relative to control | Toxoplasma gondii | 1 | ALA3769379 | organism-based format | Scientific Literature | |
13. | ALA3773439 | Functional | Antiprotozoan activity against Toxoplasma gondii overexpressing CDPK1 G128M mutant infected in fibroblasts assessed as growth inhibition at high concentration after 2 days by beta-galactosidase reporter assay | Toxoplasma gondii | 2 | ALA3769379 | organism-based format | Scientific Literature | |
14. | ALA3832817 | Functional | AntiToxoplasma gondii activity data Inhibition of plaque forming efficiency (%) Experiment A | Toxoplasma gondii | 15 | ALA3832761 | organism-based format | MMV Pathogen Box | |
15. | ALA3832818 | Functional | AntiToxoplasma gondii activity data Inhibition of plaque forming efficiency (%) Experiment B | Toxoplasma gondii | 6 | ALA3832761 | organism-based format | MMV Pathogen Box | |
16. | ALA3832819 | Functional | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment C | Toxoplasma gondii | 15 | ALA3832761 | organism-based format | MMV Pathogen Box | |
17. | ALA3832820 | Functional | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment D | Toxoplasma gondii | 15 | ALA3832761 | organism-based format | MMV Pathogen Box | |
18. | ALA3832821 | Functional | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment E | Toxoplasma gondii | 15 | ALA3832761 | organism-based format | MMV Pathogen Box | |
19. | ALA3832822 | Functional | AntiToxoplasma gondii activity data 2-day killing assay: IC50 (uM), Experiment F | Toxoplasma gondii | 14 | ALA3832761 | organism-based format | MMV Pathogen Box | |
20. | ALA3832823 | Functional | AntiToxoplasma gondii activity data 2-day killing assay: IC50 (uM), Experiment G | Toxoplasma gondii | 9 | ALA3832761 | organism-based format | MMV Pathogen Box |