Cmax in woodchuck hepatitis virus-negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg iv followed by after 4 weeks washout period administered 33.3 mg/kg, po
AUC (0 to infinity) in woodchuck hepatitis virus-negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose
AUC (0 to infinity) in woodchuck hepatitis virus-negative woodchucks at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
AUC (0 to infinity) in woodchuck hepatitis virus -negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
Terminal elimination half life in woodchuck hepatitis virus-negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose
Terminal elimination half life in woodchuck hepatitis virus-negative woodchucks at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
Terminal elimination half life in woodchuck hepatitis virus -negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
Toxicity in woodchuck hepatitis virus chronically infected woodchuck assessed as serum alanine aminotransferase level at 30 mg/kg/day, po after 4 weeks
Oral bioavailability in woodchuck hepatitis virus-negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
Cmax in woodchuck hepatitis virus-negative woodchucks at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period