Antiviral activity against Encephalomyocarditis virus EMC infected in human HeLa assessed as inhibition of virus-induced cytopathic effect after 2 days by MTT assay
Antiviral activity against Encephalomyocarditis virus infected in CF-1 mouse assessed as host survival time ratio at 10 mg/kg, sc administered 28, 22, 2 hrs before and 2 hrs after virus inoculation
Antiviral activity against Encephalomyocarditis virus infected in CF-1 mouse assessed as host survival time ratio at 50 mg/kg, sc administered 28, 22, 2 hrs before and 2 hrs after virus inoculation
Antiviral activity against Encephalomyocarditis virus infected in CF-1 mouse assessed as host survival time ratio at 250 mg/kg, sc administered 28, 22, 2 hrs before and 2 hrs after virus inoculation
Antiviral activity against Encephalomyocarditis virus infected in CF-1 mouse assessed as host survival time ratio at 50 mg/kg, po administered via gavage at 28, 22, 2 hrs before and 2 hrs after virus inoculation
Antiviral activity against Encephalomyocarditis virus infected in CF-1 mouse assessed as host survival time ratio at 250 mg/kg, po administered via gavage as single dose at 22 to 28 hrs before virus inoculation
Antiviral activity against Encephalomyocarditis virus infected in CF-1 mouse assessed as host survival time ratio at 250 mg/kg, sc administered as single dose at 22 hrs before virus inoculation
Antiviral activity against Encephalomyocarditis virus infected in HEK293 cells assessed as reduction of viral titer at 25 uM by plaque reduction assay relative to untreated control