Tested for inhibition against Helicase activity of Japanese encephalitis virus (JEV) in presence of ATP adjusted to 235 uM and 4.7 pM of RNA duplex substrate
Tested for inhibition of virus-induced cytopathogenic effect and cytotoxicity of compound against Japanese encephalitis virus with najayama strain in vero cell
Antiviral activity against Japanese encephalitis virus RP-9 infected in C57BL/6 mouse assessed as mouse survival rate at 1 ug, ip administered one day before and 1 day after viral infection measured after 25 days post infection relative to solvent treated control
Antiviral activity against Japanese encephalitis virus RP-9 infected in Stat-1-knockout immunodeficient C57BL/6 mouse assessed as mouse survival rate at 1 ug, ip administered one day before and 1 day after viral infection measured after 25 days post infection relative to solvent treated control
Antiviral activity against Japanese encephalitis virus RP-9 infected in Ig-mu chain-knockout immunodeficient C57BL/6 mouse assessed as mouse survival rate at 1 ug, ip administered one day before and 1 day after viral infection measured after 25 days post infection relative to solvent treated control
Antiviral activity against Japanese encephalitis virus RP-9 infected in CD8-alpha chain-knockout immunodeficient C57BL/6 mouse assessed as mouse survival rate at 1 ug, ip administered one day before and 1 day after viral infection measured after 25 days post infection relative to solvent treated control
Antiviral activity against Japanese encephalitis virus RP-9 infected in C57BL/6 mouse assessed as mouse survival rate at 1 ug, ip administered one day before viral infection measured after 25 days post infection relative to solvent treated control
Antiviral activity against Japanese encephalitis virus RP-9 infected in C57BL/6 mouse assessed as mouse survival rate at 1 ug, ip administered simultaneously with viral infection measured after 25 days post infection relative to solvent treated control
Antiviral activity against Japanese encephalitis virus RP-9 infected in C57BL/6 mouse assessed as mouse survival rate at 1 ug, ip administered one day after viral infection measured after 25 days post infection relative to solvent treated control
Antiviral activity against Japanese encephalitis virus GP78 infected BALB/c mouse assessed as reduction in mortality rate at 25 mg/kg, ip twice daily administered 1 day post viral-challenge
Antiviral activity against Japanese encephalitis virus GP78 infected BALB/c mouse assessed as reduction of activated microglia in mouse brain at 25 mg/kg, ip twice daily
Antiviral activity against Japanese encephalitis virus GP78 infected BALB/c mouse assessed as inhibition of viral proteins in mouse brain at 25 mg/kg, ip twice daily after 8 to 9 days by immunoblot
Antiviral activity against Japanese encephalitis virus GP78 infected BALB/c mouse assessed as inhibition of viral mRNA transcript in mouse brain at 25 mg/kg, ip twice daily after 8 to 9 days