# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1036148 | Binding | Binding affinity to TRalpha up to 10 uM | 1 | ALA1158459 | single protein format | Scientific Literature | ||
2. | ALA1036157 | Binding | Activity at TRalpha receptor up to 10 uM by transactivation assay | 1 | ALA1158459 | single protein format | Scientific Literature | ||
3. | ALA1034537 | Binding | Inhibition of SRC2 binding to TRalpha receptor ligand binding domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | 61 | ALA1151935 | assay format | Scientific Literature | ||
4. | ALA1015264 | Binding | Increase in transcriptional activity of TRalpha ligand binding domain expressed in human Hep G2 cells co-transfected with Gal4-DBD by luciferase reporter gene assay | 2 | ALA1151755 | cell-based format | Scientific Literature | ||
5. | ALA814590 | Binding | Effect on CHO-K1 cells stably transfected with Thyroid hormone receptor alpha (TRalpha1) and an alkaline phosphate reporter gene downstream thyroid response element TRAF-alpha1 was determined | Homo sapiens | 4 | ALA1136772 | cell-based format | Scientific Literature | |
6. | ALA873891 | Binding | Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor alpha) was determined | Homo sapiens | 10 | ALA1136772 | single protein format | Scientific Literature | |
7. | ALA814591 | Binding | Inhibitory activity expressed as concentration required to inhibit the binding of [125I]T3 to human thyroid hormone-alpha | 5 | ALA1131011 | single protein format | Scientific Literature | ||
8. | ALA814592 | Binding | Inhibitory activity expressed as concentration required to inhibit the binding of [125I]T3 to human thyroid hormone-alpha; NA =Inactive | 9 | ALA1131011 | single protein format | Scientific Literature | ||
9. | ALA814593 | Binding | Binding affinity towards thyroid hormone receptor (hTR alpha 1) | Homo sapiens | 6 | ALA1134818 | single protein format | Scientific Literature | |
10. | ALA814594 | Binding | Activation of human Thyroid hormone receptor alpha1 (hTRalpha1) | Homo sapiens | 4 | ALA1135520 | single protein format | Scientific Literature | |
11. | ALA885330 | Binding | Effective concentration binding towards TRalpha in E25B2 cells (agonistic activity) | 3 | ALA1136512 | cell-based format | Scientific Literature | ||
12. | ALA814595 | Binding | Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1) | 2 | ALA1135520 | single protein format | Scientific Literature | ||
13. | ALA814596 | Binding | Concentration required to inhibit 50% of binding of [125I]-T3 to human Thyroid hormone receptor alpha-1 in CHO-K1 cells | 4 | ALA1136014 | cell-based format | Scientific Literature | ||
14. | ALA814597 | Binding | Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1) | Homo sapiens | 2 | ALA1135520 | single protein format | Scientific Literature | |
15. | ALA814598 | Binding | Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3 | Homo sapiens | 7 | ALA1135520 | single protein format | Scientific Literature | |
16. | ALA814599 | Binding | Binding affinity of compound was determined against Thyroid hormone receptor alpha1 | 6 | ALA1145987 | single protein format | Scientific Literature | ||
17. | ALA947316 | Binding | Displacement of radiolabeled triiodothyronine from human thyroid hormone receptor alpha by filter paper assay | Homo sapiens | 2 | ALA1152299 | single protein format | Scientific Literature | |
18. | ALA949479 | Binding | Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | Homo sapiens | 27 | ALA1152303 | single protein format | Scientific Literature | |
19. | ALA986567 | Functional | Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells at 0.001 uM by TRE-luciferase assay | Homo sapiens | 17 | ALA1155100 | cell-based format | Scientific Literature | |
20. | ALA986568 | Functional | Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells at 0.01 uM by TRE-luciferase assay | Homo sapiens | 17 | ALA1155100 | cell-based format | Scientific Literature |