# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1058055 | Functional | Growth inhibition of human tarceva and iressa-resistant NCI-H1975 cells assessed as ATP level after 4 days | Homo sapiens | 2 | ALA1153018 | cell-based format | Scientific Literature | |
2. | ALA1058065 | Functional | Induction of mutant EGFR degradation in human tarceva and iressa-resistant NCI-H1975 cells at 20 to 500 nM by Western blotting | Homo sapiens | 1 | ALA1153018 | cell-based format | Scientific Literature | |
3. | ALA1058066 | Functional | Induction of mutant Met degradation in human tarceva and iressa-resistant NCI-H1975 cells at 20 to 500 nM by Western blotting | Homo sapiens | 1 | ALA1153018 | cell-based format | Scientific Literature | |
4. | ALA1058067 | Functional | Induction of mutant p-Akt degradation in human tarceva and iressa-resistant NCI-H1975 cells at 20 to 500 nM by Western blotting | Homo sapiens | 1 | ALA1153018 | cell-based format | Scientific Literature | |
5. | ALA1058068 | Functional | Induction of mutant c-Raf degradation in human tarceva and iressa-resistant NCI-H1975 cells at 20 to 500 nM by Western blotting | Homo sapiens | 1 | ALA1153018 | cell-based format | Scientific Literature | |
6. | ALA1058069 | Functional | Induction of mutant Cyclin D degradation in human tarceva and iressa-resistant NCI-H1975 cells at 20 to 500 nM by Western blotting | Homo sapiens | 1 | ALA1153018 | cell-based format | Scientific Literature | |
7. | ALA1058070 | Functional | Induction of mutant Cdk4 degradation in human tarceva and iressa-resistant NCI-H1975 cells at 20 to 500 nM by Western blotting | Homo sapiens | 1 | ALA1153018 | cell-based format | Scientific Literature | |
8. | ALA1044058 | Functional | Cytotoxicity against human NCI-H1975 cells after 24 hrs by MTT assay | Homo sapiens | 4 | ALA1154692 | cell-based format | Scientific Literature | |
9. | ALA968602 | Functional | Cytotoxicity against human NCI-H1975 cells assessed as fraction of viable cells after 72 hrs relative to control | Homo sapiens | 13 | ALA1149823 | cell-based format | Scientific Literature | |
10. | ALA982570 | Functional | Cytotoxicity against human NCI-H1975 cells at 200 nM assessed as fraction of viable cells after 72 hrs relative to control | Homo sapiens | 2 | ALA1149823 | cell-based format | Scientific Literature | |
11. | ALA866023 | Functional | Cytotoxicity against human NCI-H1975 cell line by MTT assay | Homo sapiens | 7 | ALA1137431 | cell-based format | Scientific Literature | |
12. | ALA1072163 | Functional | Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA1157583 | cell-based format | Scientific Literature | |
13. | ALA1072805 | Functional | Cytotoxicity against human NCI-H1975 cells assessed as cell death at 5 uM after 72 hrs by propidium iodide/Hoechst staining based fluorescence microscopy | Homo sapiens | 1 | ALA1157583 | cell-based format | Scientific Literature | |
14. | ALA1072806 | Functional | Induction of apoptosis in human NCI-H1975 cells assessed as activation of caspase-3 at 5 uM after 2 days by Western blot | Homo sapiens | 1 | ALA1157583 | cell-based format | Scientific Literature | |
15. | ALA1065083 | Functional | Antitumor activity against human NCI-H1975 cells xenografted orthotopic mouse model assessed as survival at 25 mg/kg once weekly for 7 weeks relative to untreated control | Homo sapiens | 1 | ALA1157610 | organism-based format | Scientific Literature | |
16. | ALA1107918 | Functional | Cytotoxicity against human NCI-H1975 cells expressing EGFR T790M and L858R mutant at 0.001 to 10 uM after 96 hrs by cell titer-glo assay | Homo sapiens | 2 | ALA1156950 | cell-based format | Scientific Literature | |
17. | ALA1776434 | Functional | Antitumor activity against human NCI-H1975 cells xenografted in nu/nu BALB/c mouse assessed as tumor growth inhibition at 30 mg/kg, ip qd for 12 days measured on day 25 relative to control | Homo sapiens | 1 | ALA1773045 | organism-based format | Scientific Literature | |
18. | ALA1781581 | Functional | Antiproliferative activity against human NCI-H1975 cells | Homo sapiens | 1 | ALA1777797 | cell-based format | Scientific Literature | |
19. | ALA1810579 | Functional | Antiproliferative activity against human NCI-H1975 cells | Homo sapiens | 26 | ALA1806368 | cell-based format | Scientific Literature | |
20. | ALA1810884 | Functional | Antitumor activity against human NCI-H1975 cells xenografted mouse assessed as reduction of tumor growth at 12.5 mg/kg, iv | Homo sapiens | 1 | ALA1806368 | organism-based format | Scientific Literature |