# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3424685 | Functional | Neuroprotective activity against H2O2 -mediated injury in rat PC12 cells assessed as cell survival at 0.01 uM relative to control | Rattus norvegicus | 2 | ALA3421544 | cell-based format | Scientific Literature | |
2. | ALA3424686 | Functional | Neuroprotective activity against H2O2 -mediated injury in rat PC12 cells assessed as cell survival at 0.1 uM relative to control | Rattus norvegicus | 2 | ALA3421544 | cell-based format | Scientific Literature | |
3. | ALA3424687 | Functional | Neuroprotective activity against H2O2 -mediated injury in rat PC12 cells assessed as cell survival at 1 uM relative to control | Rattus norvegicus | 3 | ALA3421544 | cell-based format | Scientific Literature | |
4. | ALA3579613 | Functional | Neurotrophic activity in rat PC12 cells assessed as enhancement of NGF-induced neurite outgrowth after 48 hrs by inverted microscopic analysis | Rattus norvegicus | 6 | ALA3576864 | cell-based format | Scientific Literature | |
5. | ALA3579614 | Functional | Effect on neurite outgrowth in rat PC12 cells at 10 to 40 uM after 48 hrs by inverted microscopic analysis | Rattus norvegicus | 6 | ALA3576864 | cell-based format | Scientific Literature | |
6. | ALA3583367 | Functional | Cytoprotection activity against H2O2-induced apoptosis in rat PC12 cells assessed as reduction in apoptotic nuclei levels at 10 and 20 uM pre-incubated for 24 hrs before H2O2 exposure for 5 hrs by Hoechst 33342 staining based fluorescent microscopy | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
7. | ALA3583368 | Functional | Cytoprotection activity against 6-OHDA-induced apoptosis in rat PC12 cells assessed as reduction in apoptotic nuclei levels at 10 and 20 uM pre-incubated for 24 hrs before 6-OHDA exposure for 5 hrs by Hoechst 33342 staining based fluorescent microscopy | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
8. | ALA3584753 | Functional | Cytoprotection activity against H2O2-induced apoptosis in rat PC12 cells assessed as reduction in caspase-3 activation at 10 and 20 uM pre-incubated for 24 hrs before H2O2 exposure for 24 hrs by colorimetric assay | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
9. | ALA3584754 | Functional | Cytoprotection activity against 6-OHDA-induced apoptosis in rat PC12 cells assessed as reduction in caspase-3 activation at 10 and 20 uM pre-incubated for 24 hrs before 6-OHDA exposure for 24 hrs by colorimetric assay | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
10. | ALA3584755 | Functional | Cytoprotection activity against H2O2-induced oxidative stress in rat PC12 cells assessed as reduction in ROS generation at 10 and 20 uM pre-incubated for 24 hrs before H2O2 exposure for 5 hrs by DCFH-DA dye based fluorescent microscopy | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
11. | ALA3584756 | Functional | Cytoprotection activity against 6-OHDA-induced oxidative stress in rat PC12 cells assessed as reduction in ROS generation at 10 and 20 uM pre-incubated for 24 hrs before 6-OHDA exposure for 5 hrs by DCFH-DA dye based fluorescent microscopy | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
12. | ALA3584759 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in HO1 mRNA level at 20 uM incubated for 6 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
13. | ALA3584760 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in Trx1 mRNA level at 20 uM incubated for 6 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
14. | ALA3584761 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in NQO1 mRNA level at 20 uM incubated for 6 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
15. | ALA3584762 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in GCLC mRNA level at 20 uM incubated for 6 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
16. | ALA3584763 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in GCLM mRNA level at 20 uM incubated for 6 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
17. | ALA3584764 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in TrxR1 mRNA level at 20 uM incubated for 6 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
18. | ALA3584765 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in TrxR1 mRNA level at 20 uM incubated for 3 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
19. | ALA3584766 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in TrxR1 mRNA level at 20 uM incubated for 12 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature | |
20. | ALA3584913 | Functional | Induction of antioxidant genes expression in rat PC12 cells assessed as increase in Trx1 mRNA level at 20 uM incubated for 3 hrs by qRT-PCR method | Rattus norvegicus | 2 | ALA3580644 | cell-based format | Scientific Literature |