# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3821805 | Functional | Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay | Rattus norvegicus | 5 | ALA3817734 | cell-based format | Scientific Literature | |
2. | ALA3821806 | Functional | Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation at 1000 uM incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay | Rattus norvegicus | 1 | ALA3817734 | cell-based format | Scientific Literature | |
3. | ALA3821815 | Functional | Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation at 30 to 300 uM incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay | Rattus norvegicus | 8 | ALA3817734 | cell-based format | Scientific Literature | |
4. | ALA859575 | Functional | Cytotoxicity against basophilic leukemia RBL 2H3 cell line by MTT assay at 100 uM | Rattus norvegicus | 6 | ALA1148612 | cell-based format | Scientific Literature | |
5. | ALA868828 | Functional | Inhibition of AEA uptake in RBL2H3 cells | Rattus norvegicus | 12 | ALA1146088 | cell-based format | Scientific Literature | |
6. | ALA868882 | Functional | Inhibition of uptake of [14C]anandamide co-incubated with RBL2H3 cells expressing AEA membrane transporter | Rattus norvegicus | 21 | ALA1146089 | cell-based format | Scientific Literature | |
7. | ALA868881 | Functional | Inhibition of uptake of [14C]anandamide pre-incubated for 1 hr with intact RBL2H3 cells expressing AEA membrane transporter | Rattus norvegicus | 18 | ALA1146089 | cell-based format | Scientific Literature | |
8. | ALA907005 | Functional | Inhibition of DNP7-BSA antigen-induced TNFalpha release in rat RBL-2H3 cells | Rattus norvegicus | 4 | ALA1137286 | cell-based format | Scientific Literature | |
9. | ALA902590 | Functional | Inhibition of anandamide uptake in RBL-2H3 cells upto 25 uM after 5 mins by anandamide membrane transport assay | Rattus norvegicus | 4 | ALA1138335 | cell-based format | Scientific Literature | |
10. | ALA1117433 | Functional | Inhibition of anti-DNP-IgE-induced degranulation in rat RBL2H3 cells assessed as betahexosaminidase released at 10 uM after 20 mins by microplate reader assay | Rattus norvegicus | 13 | ALA1157920 | cell-based format | Scientific Literature | |
11. | ALA1117434 | Functional | Inhibition of anti-DNP-IgE-induced degranulation in rat RBL2H3 cells assessed as betahexosaminidase released at 100 uM after 20 mins by microplate reader assay | Rattus norvegicus | 12 | ALA1157920 | cell-based format | Scientific Literature | |
12. | ALA1167905 | Functional | Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release | Rattus norvegicus | 7 | ALA1165854 | cell-based format | Scientific Literature | |
13. | ALA1167907 | Functional | Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release at 25 uM | Rattus norvegicus | 4 | ALA1165854 | cell-based format | Scientific Literature | |
14. | ALA1167908 | Functional | Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release at 10 uM | Rattus norvegicus | 5 | ALA1165854 | cell-based format | Scientific Literature | |
15. | ALA1226858 | Functional | Induction of GFP-PKCdelta translocation from cytoplasm to nuclear in RBL2H3 cells at 200 nM over 30 mins by fluorescent imaging | Rattus norvegicus | 1 | ALA1221165 | cell-based format | Scientific Literature | |
16. | ALA1226859 | Functional | Induction of GFP-PKCdelta translocation from cytoplasm to plasma membrane in RBL2H3 cells at 200 nM over 30 mins by fluorescent imaging | Rattus norvegicus | 1 | ALA1221165 | cell-based format | Scientific Literature | |
17. | ALA1226860 | Functional | Induction of GFP-PKCdelta translocation from cytoplasm to nuclear in RBL2H3 cells at 5 uM over 30 mins by fluorescent imaging | Rattus norvegicus | 1 | ALA1221165 | cell-based format | Scientific Literature | |
18. | ALA1251080 | Functional | Antiallergic activity against antigen-IgE-mediated degranulation in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced intracellular pathway at 50 uM after 30 mins | Rattus norvegicus | 2 | ALA1250527 | cell-based format | Scientific Literature | |
19. | ALA1251081 | Functional | Antiallergic activity against antigen-IgE-mediated degranulation in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release at 10 to 100 uM | Rattus norvegicus | 2 | ALA1250527 | cell-based format | Scientific Literature | |
20. | ALA1251082 | Functional | Antiallergic activity against antigen-IgE-mediated degranulation in rat RBL2H3 cells assessed as reduction in DNP-BSA-induced intracellular calcium level at 50 uM after 30 mins | Rattus norvegicus | 2 | ALA1250527 | cell-based format | Scientific Literature |