Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as tumor growth inhibition at 0.2 mg/kg, iv administered on day 8 post-tumor injection for 7 days measured on day 16 relative to vehicle treated control
Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as tumor growth inhibition at 5 mg/kg, iv administered on day 8 post-tumor injection for 7 days measured on day 16 relative to vehicle treated control
Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as decrease in cell survival at 0.2 mg/kg, iv administered on day 8 post-tumor injection for 7 days measured on day 16 by hematoxylin and eosin staining relative to vehicle treated control
Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as decrease in cell survival at 5 mg/kg, iv administered on day 8 post-tumor injection for 7 days measured on day 16 relative to vehicle treated control
Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as median survival time at 0.2 mk/kg, iv administered 24 hrs post-tumor injection for 7 days (Rvb = 12.7 +/- 2.5 days)
Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as median survival time at 5 mk/kg, iv administered 24 hrs post-tumor injection for 7 days (Rvb = 12.7 +/- 2.5 days)
Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as median survival time at 0.2 mk/kg, iv administered 24 hrs post-tumor injection for 7 days relative to vehicle treated control
Antitumor activity against mouse H22 cells xenografted in Kunming mouse assessed as median survival time at 5 mk/kg, iv administered 24 hrs post-tumor injection for 7 days relative to vehicle treated control
Antimetastatic activity against mouse H22 cells xenografted in Kunming mouse assessed as decrease in lung tumor burden at 0.2 mg/kg, iv administered on day 11 post-tumor injection for 7 days measured on day 18 relative to vehicle treated control
Antimetastatic activity against mouse H22 cells xenografted in Kunming mouse assessed as decrease in lung metastases nodus number at 5 mg/kg, iv administered on day 11 post-tumor injection for 7 days measured on day 18 by hematoxylin and eosin staining relative to vehicle treated control
Antimetastatic activity against mouse H22 cells xenografted in Kunming mouse assessed as decrease in lung metastasis focuses at 0.2 mg/kg, iv administered on day 11 post-tumor injection for 7 days measured on day 18 relative to vehicle treated control
Antimetastatic activity against mouse H22 cells xenografted in Kunming mouse assessed as decrease in lung metastasis focuses number at 5 mg/kg, iv administered on day 11 post-tumor injection for 7 days measured on day 18 by hematoxylin and eosin staining relative to vehicle treated control
Antimetastatic activity against mouse H22 cells xenografted in Kunming mouse assessed as tumor weight at 0.2 mg/kg, iv administered on day 11 post-tumor injection for 7 days measured on day 18 (Rvb = 0.34 +/- 0.15 g)
Antimetastatic activity against mouse H22 cells xenografted in Kunming mouse assessed as tumor weight at 5 mg/kg, iv administered on day 11 post-tumor injection for 7 days measured on day 18 (Rvb = 0.34 +/- 0.15 g)