| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA696499 | B | Tested for inhibition of human ribonucleotide reductase | 6 | single protein format | Scientific Literature | |||
| 2. | ALA797485 | B | Inhibitory concentration against HSV-1 ribonucleotide reductase R1 protein binding relative to Ac-VZV R2-(298-306) | herpes simplex virus | 9 | single protein format | Scientific Literature | ||
| 3. | ALA795004 | B | Inhibitory concentration against HSV-1 ribonucleotide reductase R1 protein binding | herpes simplex virus | 9 | single protein format | Scientific Literature | ||
| 4. | ALA802419 | B | Inhibitory concentration against HSV-1 ribonucleotide reductase R1 protein binding relative to Ac-VZV R2-(298-306) | herpes simplex virus | 19 | single protein format | Scientific Literature | ||
| 5. | ALA802420 | B | Inhibitory against HSV-1 ribonucleotide reductase R1 protein binding relative to Ac-VZV R2-(298-306); No data | herpes simplex virus | 4 | single protein format | Scientific Literature | ||
| 6. | ALA879246 | B | Inhibitory concentration against HSV-1 ribonucleotide reductase R1 protein binding | herpes simplex virus | 23 | single protein format | Scientific Literature | ||
| 7. | ALA806874 | B | Inhibitory concentration against HSV-1 ribonucleotide reductase R1 protein binding; Range 30-60 | herpes simplex virus | 1 | single protein format | Scientific Literature | ||
| 8. | ALA3243357 | B | Inhibition of RRM1 in human U2OS cells assessed as gammaH2AX induction after 2 hrs by FITC/propidium iodide-staining based flow cytometry in presence of SCH900776 | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA3243390 | B | Inhibition of RRM1 in human U2OS cells assessed as gammaH2AX induction at 0.5 to 125 uM after 2 hrs by FITC/propidium iodide-staining based flow cytometry in presence of SCH900776 | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA3243394 | B | Inhibition of RRM1 in human U2OS cells assessed as gammaH2AX induction at 0.5 to 125 uM after 2 hrs by FITC/propidium iodide-staining based flow cytometry in absence of SCH900776 | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA3243396 | B | Inhibition of RRM1 in human CEM cells assessed as depletion of dATP level at 1 uM after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3243398 | B | Inhibition of RRM1 in human CEM cells assessed as depletion of dCTP level at 1 uM after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3243399 | B | Inhibition of RRM1 in human CEM cells assessed as depletion of dGTP level at 1 uM after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3750221 | B | Binding affinity to human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) at 50 uM by tryptophan fluorescence quenching assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 15. | ALA3750222 | B | Binding affinity to human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assay | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 16. | ALA3750223 | B | Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation counting analysis | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 17. | ALA3750229 | B | Noncompetitive inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) assessed as reduction of Kcat at 32 uM by double reciprocal plot analysis relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA3750230 | B | Noncompetitive inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) assessed as reduction of Kcat at 64 uM by double reciprocal plot analysis relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA3750231 | B | Effect on human ribonucleotide reductase M1 oligomerization expressed in Escherichia coli BL21 (DE3) assessed as hexamer to dimer ratio at 1 mM by gel filtration chromatography in presence of dATP | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA3750233 | B | Induction of human ribonucleotide reductase M1 dimerization expressed in Escherichia coli BL21 (DE3) at 1 mM by gel filtration chromatography relative to control | Homo sapiens | 1 | assay format | Scientific Literature |
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