Compounds

ALA5267353

Name:
1-(4-chloro-2-fluorophenyl)-3-((3R)-1-(2'-(dimethylphosphoryl)-2,3-difluoroShow More⌵

Mol. Formula:
C26H24ClF3N3O4P

M.W.:
565.92

Type:
---

AlogP:
4.82

Polar Surface Area:
98.74

HBA:
4

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.37

DETAILS

ALA5265989

Name:
(S)-3-(4-cyanophenyl)-N-((1-(3-hydroxyphenyl)cyclopropyl)methyl)-2-(3-(4-meShow More⌵

Mol. Formula:
C28H28N4O4

M.W.:
484.56

Type:
---

AlogP:
3.85

Polar Surface Area:
123.48

HBA:
5

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.37

DETAILS

ALA5265951

Name:
(R)-1-(5-chloropyridin-2-yl)-3-(1-(4-(1-(morpholinomethyl)cyclopropyl)phenyShow More⌵

Mol. Formula:
C25H30ClN5O3

M.W.:
484.00

Type:
---

AlogP:
3.42

Polar Surface Area:
86.80

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.66

DETAILS

ALA5265888

Name:
1-[(3S,4R)-4-(4-bromo-2,6-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-3-[1-(6-mShow More⌵

Mol. Formula:
C20H19BrF2N4O2

M.W.:
465.30

Type:
---

AlogP:
3.00

Polar Surface Area:
83.12

HBA:
3

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.65

DETAILS

ALA5282707

Name:
(R)-4'-(2-oxo-3-(3-(4-(trifluoromethyl)phenyl)ureido)piperidin-1-yl)-[1,1'-Show More⌵

Mol. Formula:
C26H22F3N3O4

M.W.:
497.47

Type:
---

AlogP:
5.39

Polar Surface Area:
98.74

HBA:
3

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.44

DETAILS

ALA5282261

Name:
1-(4-cyanophenyl)-3-((3S,4R)-4-(6-fluoro-2,3-dihydrobenzofuran-5-yl)-2-oxopShow More⌵

Mol. Formula:
C20H17FN4O3

M.W.:
380.38

Type:
---

AlogP:
2.04

Polar Surface Area:
103.25

HBA:
4

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.76

DETAILS

ALA5282051

Name:
(R)-1-(4-chlorophenyl)-3-(1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)urea

Mol. Formula:
C17H19ClN2O3

M.W.:
334.80

Type:
---

AlogP:
3.07

Polar Surface Area:
70.59

HBA:
3

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.76

DETAILS

ALA5282050

Name:
(R)-3-(4-hydroxyphenyl)-2-(3-(4-methoxyphenyl)ureido)-N-((1-phenylcyclopropShow More⌵

Mol. Formula:
C27H29N3O4

M.W.:
459.55

Type:
---

AlogP:
3.98

Polar Surface Area:
99.69

HBA:
4

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.39

DETAILS

ALA5281870

Name:
(S)-1-(4-chlorophenyl)-3-(1-(5-(2-hydroxyethyl)-1,2,4-oxadiazol-3-yl)-2-(4-Show More⌵

Mol. Formula:
C20H21ClN4O4

M.W.:
416.87

Type:
---

AlogP:
3.37

Polar Surface Area:
109.51

HBA:
6

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5281612

Name:
1-[(3S,4R)-4-(4-chloro-2,6-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-3-[1-(6-Show More⌵

Mol. Formula:
C20H19ClF2N4O2

M.W.:
420.85

Type:
---

AlogP:
2.89

Polar Surface Area:
83.12

HBA:
3

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.71

DETAILS

ALA5280794

Name:
(S)-3-(4-hydroxyphenyl)-2-(3-(4-methoxyphenyl)ureido)-N-((1-phenylcyclopropShow More⌵

Mol. Formula:
C27H29N3O4

M.W.:
459.55

Type:
---

AlogP:
3.98

Polar Surface Area:
99.69

HBA:
4

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.39

DETAILS

ALA5280720

Name:
(R)-N-((1-(4-(3-(3-(5-chloropyrazin-2-yl)ureido)-2-oxopiperidin-1-yl)phenylShow More⌵

Mol. Formula:
C22H27ClN6O4S

M.W.:
507.02

Type:
---

AlogP:
2.42

Polar Surface Area:
133.39

HBA:
6

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA5279627

Name:
N-(4-bromophenyl)-2-(5-(3-methoxybenzyl)-3-methyl-6-oxo-4-phenylpyridazin-1Show More⌵

Mol. Formula:
C27H24BrN3O3

M.W.:
518.41

Type:
---

AlogP:
5.22

Polar Surface Area:
73.22

HBA:
5

HBD:
1

#RO5 Violations:
2

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.36

DETAILS

ALA5279215

Name:
(S)-3-(4-cyanophenyl)-N-((1-(4-hydroxyphenyl)cyclopropyl)methyl)-2-(3-(4-meShow More⌵

Mol. Formula:
C28H28N4O4

M.W.:
484.56

Type:
---

AlogP:
3.85

Polar Surface Area:
123.48

HBA:
5

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.37

DETAILS

ALA5278986

Name:
(R)-N-(3'-fluoro-4'-(3-(3-(5-methylpyrazin-2-yl)ureido)-2-oxopiperidin-1-ylShow More⌵

Mol. Formula:
C24H25FN6O4S

M.W.:
512.57

Type:
---

AlogP:
3.28

Polar Surface Area:
133.39

HBA:
6

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA5278883

Name:
N-(4-bromophenyl)-2-(5-cyano-3-(3-methoxyphenyl)-6-methyl-2-oxopyridin-1(2HShow More⌵

Mol. Formula:
C22H18BrN3O3

M.W.:
452.31

Type:
---

AlogP:
4.11

Polar Surface Area:
84.12

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.63

DETAILS

ALA5278412

Name:
(S)-1-(1-(2'-fluoro-[1,1'-biphenyl]-4-yl)-2-oxopiperidin-3-yl)-3-(4-(trifluShow More⌵

Mol. Formula:
C25H21F4N3O2

M.W.:
471.45

Type:
---

AlogP:
5.83

Polar Surface Area:
61.44

HBA:
2

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5277975

Name:
(R)-4'-(3-(3-(4-chlorophenyl)ureido)-2-oxopiperidin-1-yl)-[1,1'-biphenyl]-2Show More⌵

Mol. Formula:
C25H23ClN4O3

M.W.:
462.94

Type:
---

AlogP:
4.42

Polar Surface Area:
104.53

HBA:
3

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5277650

Name:
(R)-1-(1-(4-(4-acetylpiperazin-1-yl)phenyl)-2-oxopiperidin-3-yl)-3-(4-(trifShow More⌵

Mol. Formula:
C25H28F3N5O3

M.W.:
503.53

Type:
---

AlogP:
3.69

Polar Surface Area:
84.99

HBA:
4

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.67

DETAILS

ALA5277178

Name:
1-[(3S,4R)-4-(2,6-difluoro-4-methoxy-phenyl)-2-oxo-pyrrolidin-3-yl]-3-[1-(6Show More⌵

Mol. Formula:
C26H25F2N3O4

M.W.:
481.50

Type:
---

AlogP:
3.71

Polar Surface Area:
88.69

HBA:
4

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.50

DETAILS