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  1. ALA5288269

    Name:
    2-(4-aminophenyl)-2-fluoro-N-{3-fluoro-4-[(6-methoxy-7-propoxyquinolin-4-ylShow More

    Mol. Formula:
    C35H29F2N5O5

    M.W.:
    637.64

    Type:
    ---

    AlogP:
    7.45

    Polar Surface Area:
    134.62

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    11

    Passes Ro3:
    N

    QED Weighted:
    0.14

    DETAILS
  2. ALA5198669

    Name:
    N-cyclohexyl-3-((3-fluoro-4-((6-methoxy-7-(3-methoxypropoxy)quinolin-4-yl)oShow More

    Mol. Formula:
    C31H36FN5O5

    M.W.:
    577.66

    Type:
    ---

    AlogP:
    6.13

    Polar Surface Area:
    108.76

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    12

    Passes Ro3:
    N

    QED Weighted:
    0.19

    DETAILS
  3. ALA5198449

    Name:
    N-(4-((5-amino-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)Show More

    Mol. Formula:
    C41H43N11O4

    M.W.:
    753.87

    Type:
    ---

    AlogP:
    4.59

    Polar Surface Area:
    202.15

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    13

    Passes Ro3:
    N

    QED Weighted:
    0.08

    DETAILS
  4. ALA5197492

    Name:
    5-Chloro-N4-(2-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-N2-(4-((1-methylpipeShow More

    Mol. Formula:
    C24H26ClN9O

    M.W.:
    491.99

    Type:
    ---

    AlogP:
    4.28

    Polar Surface Area:
    105.91

    HBA:
    10

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.39

    DETAILS
  5. ALA5197327

    Name:
    3-((4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)amino)-1-methyl-N-(tShow More

    Mol. Formula:
    C27H28FN5O5

    M.W.:
    521.55

    Type:
    ---

    AlogP:
    4.57

    Polar Surface Area:
    108.76

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.35

    DETAILS
  6. ALA5197239

    Name:
    6-((5-chloro-4-((2-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)pyrimidin-2Show More

    Mol. Formula:
    C24H21ClN8O

    M.W.:
    472.94

    Type:
    ---

    AlogP:
    4.83

    Polar Surface Area:
    111.72

    HBA:
    7

    HBD:
    3

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.37

    DETAILS
  7. ALA5197167

    Name:
    N-(tert-butyl)-3-((4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)aminoShow More

    Mol. Formula:
    C26H28FN5O4

    M.W.:
    493.54

    Type:
    ---

    AlogP:
    5.19

    Polar Surface Area:
    99.53

    HBA:
    8

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.37

    DETAILS
  8. ALA5196494

    Name:
    N-(2-((5-amino-1-(6-phenylpyridazin-3-yl)-1H-1,2,4-triazol-3-yl)amino)ethylShow More

    Mol. Formula:
    C35H41N11O4

    M.W.:
    679.79

    Type:
    ---

    AlogP:
    3.05

    Polar Surface Area:
    202.15

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    16

    Passes Ro3:
    N

    QED Weighted:
    0.09

    DETAILS
  9. ALA5196451

    Name:
    3-((4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)amino)-N-(3-fluorophShow More

    Mol. Formula:
    C28H23F2N5O4

    M.W.:
    531.52

    Type:
    ---

    AlogP:
    6.05

    Polar Surface Area:
    99.53

    HBA:
    8

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.25

    DETAILS
  10. ALA5205244

    Name:
    1-(4-(4-((5-Chloro-4-((2-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-amino)pyriShow More

    Mol. Formula:
    C25H26ClN9O

    M.W.:
    504.00

    Type:
    ---

    AlogP:
    4.08

    Polar Surface Area:
    104.10

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.41

    DETAILS
  11. ALA5205234

    Name:
    N-(4-((5-amino-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)Show More

    Mol. Formula:
    C40H41N11O4

    M.W.:
    739.84

    Type:
    ---

    AlogP:
    4.20

    Polar Surface Area:
    202.15

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    12

    Passes Ro3:
    N

    QED Weighted:
    0.09

    DETAILS
  12. ALA5204838

    Name:
    5-Chloro-N2-(3-fluoro-4-((1-methylpiperidin-4-yl)oxy)phenyl)-N4-(2-(5-methyShow More

    Mol. Formula:
    C25H26ClFN8O

    M.W.:
    508.99

    Type:
    ---

    AlogP:
    5.32

    Polar Surface Area:
    103.88

    HBA:
    8

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.31

    DETAILS
  13. ALA5204819

    Name:
    2-((5-chloro-2-((2-((1-methylpiperidin-4-yl)methyl)-[1,2,4]-triazolo[1,5-a]Show More

    Mol. Formula:
    C25H30ClN9O2S

    M.W.:
    556.10

    Type:
    ---

    AlogP:
    3.79

    Polar Surface Area:
    120.65

    HBA:
    10

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.33

    DETAILS
  14. ALA5203409

    Name:
    5-Chloro-N4-(2-(1-ethyl-5-methyl-1H-1,2,4-triazol-3-yl)phenyl)-N2-(4-((1-meShow More

    Mol. Formula:
    C27H31ClN8O

    M.W.:
    519.05

    Type:
    ---

    AlogP:
    5.68

    Polar Surface Area:
    93.02

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.31

    DETAILS
  15. ALA5202025

    Name:
    5-Chloro-N2-(4-(4-(dimethylamino)piperidin-1-yl)phenyl)-N4-(2-(5-methyl-1H-Show More

    Mol. Formula:
    C26H30ClN9

    M.W.:
    504.04

    Type:
    ---

    AlogP:
    5.24

    Polar Surface Area:
    97.89

    HBA:
    8

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.31

    DETAILS
  16. ALA5201640

    Name:
    (4-((5-Chloro-4-((2-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)pyrimidin-Show More

    Mol. Formula:
    C25H26ClN9O

    M.W.:
    504.00

    Type:
    ---

    AlogP:
    4.10

    Polar Surface Area:
    114.96

    HBA:
    8

    HBD:
    3

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.36

    DETAILS
  17. ALA5200544

    Name:
    N-(2-((5-amino-1-(6-phenylpyridazin-3-yl)-1H-1,2,4-triazol-3-yl)amino)ethylShow More

    Mol. Formula:
    C31H33N11O4

    M.W.:
    623.68

    Type:
    ---

    AlogP:
    1.49

    Polar Surface Area:
    202.15

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    12

    Passes Ro3:
    N

    QED Weighted:
    0.11

    DETAILS
  18. ALA5199546

    Name:
    N-(2-((5-amino-1-(6-phenylpyridazin-3-yl)-1H-1,2,4-triazol-3-yl)amino)ethylShow More

    Mol. Formula:
    C33H37N11O4

    M.W.:
    651.73

    Type:
    ---

    AlogP:
    2.27

    Polar Surface Area:
    202.15

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    14

    Passes Ro3:
    N

    QED Weighted:
    0.10

    DETAILS
  19. ALA5199302

    Name:
    1-(4-(4-((5-Chloro-4-((2-(1,5-dimethyl-1H-1,2,4-triazol-3-yl)phenyl)amino)pShow More

    Mol. Formula:
    C26H28ClN9O

    M.W.:
    518.03

    Type:
    ---

    AlogP:
    4.39

    Polar Surface Area:
    104.10

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.39

    DETAILS
  20. ALA5209500

    Name:
    5-Chloro-N2-(4-(methyl(1-methylpiperidin-4-yl)amino)phenyl)-N4-(2-(5-methylShow More

    Mol. Formula:
    C26H30ClN9

    M.W.:
    504.04

    Type:
    ---

    AlogP:
    5.24

    Polar Surface Area:
    97.89

    HBA:
    8

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.31

    DETAILS
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